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    janA janus A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43569, updated on 10-May-2024

    Summary

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    Official Symbol
    janAprovided by FlyBase
    Official Full Name
    janus Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0001280
    Locus tag
    Dmel_CG7933
    See related
    AllianceGenome:FB:FBgn0001280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:AT12574; CG7933; Dmel\CG7933; jan; Jan; jan A; janus; Y
    Summary
    Predicted to enable protein histidine phosphatase activity. Involved in sex differentiation. Predicted to be active in cytosol. Is expressed in several structures, including extended germ band embryo; germ layer; gonad; gut section; and stage 5 embryo. Orthologous to human PHPT1 (phosphohistidine phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See janA in Genome Data Viewer
    Location:
    99D3-99D3; 3-100 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (30038622..30039533, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (25864344..25865255, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Axin Neighboring gene Zinc-finger protein interacting with CP190 Neighboring gene ocnus Neighboring gene janus B Neighboring gene Serendipity alpha Neighboring gene Serendipity beta Neighboring gene Serendipity delta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Drosophila maternal and embryo mRNAs transcribed from a single transcription unit use alternate combinations of exons. Vincent A, et al. EMBO J, 1984 May. PMID 6329730, Free PMC Article
    2. Patterns of DNA sequence variation suggest the recent action of positive selection in the janus-ocnus region of Drosophila simulans. Parsch J, et al. Genetics, 2001 Oct. PMID 11606541, Free PMC Article
    3. Sequence and structure of the serendipity locus of Drosophila melanogaster. A densely transcribed region including a blastoderm-specific gene. Vincent A, et al. J Mol Biol, 1985 Nov 5. PMID 3935797
    4. Transcriptional and translational cis-regulatory sequences of the spermatocyte-specific Drosophila janusB gene are located in the 3' exonic region of the overlapping janusA gene. Yanicostas C, et al. Mol Gen Genet, 1990 Dec. PMID 2125114
    5. The serendipity alpha gene encodes a membrane-associated protein required for the cellularization of the Drosophila embryo. Schweisguth F, et al. Genes Dev, 1990 Jun. PMID 2166703

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein histidine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-histidine dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sex differentiation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    janus A
    Names
    CG7933-PA
    CG7933-PB
    CG7933-PC
    janA-PA
    janA-PB
    janA-PC
    janus
    NP_788762.1
    NP_788763.1
    NP_996311.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      30038622..30039533 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_206588.2 → NP_996311.1  janus A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996311.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA86
      Conserved Domains (1) summary
      pfam05005
      Location:9 → 108
      Ocnus; Janus/Ocnus family (Ocnus)

    2. NM_176586.4 → NP_788763.1  janus A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LA86
      Related
      FBpp0089165
      Conserved Domains (1) summary
      pfam05005
      Location:9 → 108
      Ocnus; Janus/Ocnus family (Ocnus)

    3. NM_176585.2 → NP_788762.1  janus A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788762.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3M6, P20348, Q8T475, Q9VAB6
      UniProtKB/TrEMBL
      C7LA86
      Related
      FBpp0084962
      Conserved Domains (1) summary
      pfam05005
      Location:25 → 124
      Ocnus; Janus/Ocnus family (Ocnus)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P20348.2 P20348

    Gene LinkOut

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