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    NUCB1 Nucleobindin 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39978, updated on 10-May-2024

    Summary

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    Official Symbol
    NUCB1provided by FlyBase
    Official Full Name
    Nucleobindin 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0052190
    Locus tag
    Dmel_CG32190
    See related
    AllianceGenome:FB:FBgn0052190
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32190; CG5587; Dmel\CG32190; dmnucb1; nucb1; NucB1
    Summary
    Predicted to enable calcium ion binding activity. Involved in defense response to Gram-negative bacterium. Located in Golgi apparatus. Is expressed in adult head; embryonic/larval salivary gland; embryonic/larval salivary gland body; organism; and salivary gland body primordium. Orthologous to human NUCB1 (nucleobindin 1) and NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See NUCB1 in Genome Data Viewer
    Location:
    75A2-75A2; 3-45 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17797738..17802279, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17790838..17795379, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene aramis Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NUCB1, the Drosophila melanogaster homolog of the mammalian EF-hand proteins NEFA and nucleobindin. Otte S, et al. Mech Dev, 1999 Aug. PMID 10446275
    2. Direct dye terminator sequencing of lambda DNA and phage suspensions. Otte S, et al. Anal Biochem, 1999 Jun 1. PMID 10334852
    3. Glycosylation signatures in Drosophila: fishing with lectins. Vandenborre G, et al. J Proteome Res, 2010 Jun 4. PMID 20387871
    4. Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis. Balasubramanian V, et al. Genome, 2020 Feb. PMID 31557446
    5. Tumour-derived Dilp8/INSL3 induces cancer anorexia by regulating feeding neuropeptides via Lgr3/8 in the brain. Yeom E, et al. Nat Cell Biol, 2021 Feb. PMID 33558728

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. NUCB1 is required for proper insulin signaling to control longevity in Drosophila.
      Title: NUCB1 is required for proper insulin signaling to control longevity in Drosophila.
    2. Important modulatory functions for Drosophila NUCB1 in intracellular IP3-mediated Ca2+ homeostasis.
      Title: Genetic analyses uncover pleiotropic compensatory roles for Drosophila Nucleobindin-1 in inositol trisphosphate-mediated intracellular calcium homeostasis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c17801595-17799864 mobile_element_type = transposon:S{}1026

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endomembrane system HDA PubMed 
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    nucleobindin 1
    Names
    CG32190-PA
    NUCB1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17797738..17802279 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140751.4 → NP_649008.2  nucleobindin 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649008.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VVK7
      Related
      FBpp0074937
      Conserved Domains (3) summary
      cl21499
      Location:87 → 156
      SPX; Domain found in Syg1, Pho81, XPR1, and related proteins
      pfam13499
      Location:241 → 313
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:244 → 313
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O16124 O16124
    O44117 O44117
    Q7KQC2 Q7KQC2
    Q9VVK7 Q9VVK7

    Gene LinkOut

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