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    CG14893 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42023, updated on 10-May-2024

    Summary

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    Official Symbol
    CG14893provided by FlyBase
    Primary source
    FLYBASE:FBgn0038451
    Locus tag
    Dmel_CG14893
    See related
    AllianceGenome:FB:FBgn0038451
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CT34717; Dmel\CG14893
    Summary
    Predicted to enable fatty-acyl-CoA reductase (alcohol-forming) activity. Predicted to be involved in long-chain fatty-acyl-CoA metabolic process. Predicted to be active in peroxisome. Is expressed in adult head. Orthologous to human FAR1 (fatty acyl-CoA reductase 1) and FAR2 (fatty acyl-CoA reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG14893 in Genome Data Viewer
    Location:
    89D5-89D5; 3-59 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (16620778..16622702)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (12446500..12448424)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-2494 stem loop Neighboring gene Coiled-coil domain containing protein 114 Neighboring gene Fasciclin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural variation at a single gene generates sexual antagonism across fitness components in Drosophila. Rusuwa BB, et al. Curr Biol, 2022 Jul 25. PMID 35700732
    2. Birth-and-Death Evolution of the Fatty Acyl-CoA Reductase (FAR) Gene Family and Diversification of Cuticular Hydrocarbon Synthesis in Drosophila. Finet C, et al. Genome Biol Evol, 2019 Jun 1. PMID 31076758, Free PMC Article
    3. Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex. Gilfillan GD, et al. Genes Dev, 2006 Apr 1. PMID 16547172, Free PMC Article
    4. Transcriptome analysis provides insights for understanding the adverse effects of endosulfan in Drosophila melanogaster. Sharma A, et al. Chemosphere, 2011 Jan. PMID 21036383
    5. Transcriptional response to alcohol exposure in Drosophila melanogaster. Morozova TV, et al. Genome Biol, 2006. PMID 17054780, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in long-chain fatty-acyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG14893-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      16620778..16622702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142311.4 → NP_650568.2  uncharacterized protein Dmel_CG14893 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650568.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q4V5M4, Q9VES5
      Conserved Domains (3) summary
      cd05236
      Location:23 → 339
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:19 → 452
      PLN02996; fatty acyl-CoA reductase
      pfam03015
      Location:375 → 465
      Sterile; Male sterility protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VES5 Q9VES5

    Gene LinkOut

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