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    Cyp4ac3 Cytochrome P450 4ac3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33756, updated on 10-May-2024

    Summary

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    Official Symbol
    Cyp4ac3provided by FlyBase
    Official Full Name
    Cytochrome P450 4ac3provided by FlyBase
    Primary source
    FLYBASE:FBgn0031695
    Locus tag
    Dmel_CG14031
    See related
    AllianceGenome:FB:FBgn0031695
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4ac3; CG14031; Cyp4AC3; CYP4AC3; Dmel\CG14031
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head; embryonic/larval midgut; and gastric caecum. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Cyp4ac3 in Genome Data Viewer
    Location:
    25D2-25D2; 2-16 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5268498..5270329)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5268498..5270329)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene thickveins Neighboring gene Cytochrome P450 4ac1 Neighboring gene Cytochrome P450 4ac2 Neighboring gene Ninein Neighboring gene Bub1 kinase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression and down-regulation of cytochrome P450 genes of the CYP4 family by ecdysteroid agonists in Spodoptera littoralis and Drosophila melanogaster. Davies L, et al. Insect Biochem Mol Biol, 2006 Oct. PMID 17027846
    2. Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway. Jones RM, et al. Cell Rep, 2015 Aug 25. PMID 26279578, Free PMC Article
    3. Structural Modeling of Drosophila melanogaster Gut Cytochrome P450s and Docking Comparison of Fruit Fly Gut and Human Cytochrome P450s. Nirusimhan V, et al. Curr Drug Metab, 2022. PMID 35546755
    4. Regulation of cytochrome P450 expression in Drosophila: Genomic insights. Giraudo M, et al. Pestic Biochem Physiol, 2010 Jun 1. PMID 20582327, Free PMC Article
    5. High fat diet induces sex-specific differential gene expression in Drosophila melanogaster. Stobdan T, et al. PLoS One, 2019. PMID 30861021, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4ac3
    Names
    CG14031-PA
    Cyp4ac3-PA
    cytochrome P450
    NP_608918.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      5268498..5270329
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135074.3 → NP_608918.1  cytochrome P450 4ac3 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VMS7
      Related
      FBpp0078703
      Conserved Domains (1) summary
      pfam00067
      Location:51 → 504
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMS7.2 Q9VMS7

    Gene LinkOut

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