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    Dnajc12 DnaJ heat shock protein family (Hsp40) member C12 [ Mus musculus (house mouse) ]

    Gene ID: 30045, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Dnajc12provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C12provided by MGI
    Primary source
    MGI:MGI:1353428
    See related
    Ensembl:ENSMUSG00000036764 AllianceGenome:MGI:1353428
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jdp1; mJDP1
    Summary
    Predicted to be located in cytoplasm. Is expressed in brain; gut; and liver lobe. Orthologous to human DNAJC12 (DnaJ heat shock protein family (Hsp40) member C12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in kidney adult (RPKM 26.8), cerebellum adult (RPKM 7.5) and 16 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnajc12 in Genome Data Viewer
    Location:
    10 B4; 10 32.57 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63218222..63244619)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63382443..63408840)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene hect domain and RLD 4 Neighboring gene predicted gene, 51767 Neighboring gene sirtuin 1 Neighboring gene Sirt1 promoter region Neighboring gene STARR-seq mESC enhancer starr_26931 Neighboring gene STARR-seq mESC enhancer starr_26932 Neighboring gene STARR-positive B cell enhancer ABC_E5142 Neighboring gene calcyclin binding protein pseudogene Neighboring gene ring finger protein 7 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Structural analysis of phylogenetically conserved J domain protein gene. Hahn Y, et al. Biochim Biophys Acta, 1999 Oct 28. PMID 10542335
    2. Characterization of JDP genes, an evolutionarily conserved J domain-only protein family, from human and moths. Lee J, et al. Biochim Biophys Acta, 2000 Apr 25. PMID 10760603
    3. Gene- and tissue-level interactions in normal gastrointestinal development and Hirschsprung disease. Chatterjee S, et al. Proc Natl Acad Sci U S A, 2019 Dec 26. PMID 31818953, Free PMC Article
    4. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
    5. The human (PEDB) and mouse (mPEDB) Prostate Expression Databases. Nelson PS, et al. Nucleic Acids Res, 2002 Jan 1. PMID 11752298, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    dnaJ homolog subfamily C member 12
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 12
    J domain protein 1
    j domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253685.1 → NP_001240614.1  dnaJ homolog subfamily C member 12 isoform 2

      See identical proteins and their annotated locations for NP_001240614.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate 5' exon and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) is significantly shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK002649, BF453706, BM899037
      UniProtKB/TrEMBL
      D3Z0D9, Q9CWA0
      Related
      ENSMUSP00000120892.2, ENSMUST00000129625.8

    2. NM_013888.3 → NP_038916.1  dnaJ homolog subfamily C member 12 isoform 1

      See identical proteins and their annotated locations for NP_038916.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC153516, AC164179, AK002649, BM899037, DV042983
      Consensus CDS
      CCDS23899.1
      UniProtKB/Swiss-Prot
      Q9R022
      Related
      ENSMUSP00000041298.6, ENSMUST00000043317.7
      Conserved Domains (1) summary
      pfam00226
      Location:14 → 76
      DnaJ; DnaJ domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63218222..63244619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9R022.1 GenPept UniProtKB/Swiss-Prot:Q9R022

    Gene LinkOut

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