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    H2bc23 H2B clustered histone 23 [ Mus musculus (house mouse) ]

    Gene ID: 665596, updated on 8-Feb-2024

    Summary

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    Official Symbol
    H2bc23provided by MGI
    Official Full Name
    H2B clustered histone 23provided by MGI
    Primary source
    MGI:MGI:3702051
    See related
    Ensembl:ENSMUSG00000069307 AllianceGenome:MGI:3702051
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm13646; Hist1h2bq
    Summary
    Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-dependent histone that is a member of the histone H2B family and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif. [provided by RefSeq, Sep 2015]
    Expression
    Ubiquitous expression in thymus adult (RPKM 100.4), colon adult (RPKM 57.3) and 24 other tissues See more
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    Genomic context

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    See H2bc23 in Genome Data Viewer
    Location:
    13 A3.1; 13 7.98 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (21990582..21994369, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (21806412..21810199, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_33864 Neighboring gene H2A clustered histone 22 Neighboring gene H2B clustered histone 22 Neighboring gene STARR-positive B cell enhancer mm9_chr13:21894945-21895245 Neighboring gene H2A clustered histone 23 Neighboring gene H4 clustered histone 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb. Wang ZF, et al. Genome Res, 1996 Aug. PMID 8858344
    2. The human and mouse replication-dependent histone genes. Marzluff WF, et al. Genomics, 2002 Nov. PMID 12408966
    3. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables STAT family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables ubiquitin-like protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    H2b histone family, member A
    Names
    histone cluster 1, H2bq

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001097979.2 → NP_001091448.2  H2b histone family, member A isoform 1

      See identical proteins and their annotated locations for NP_001091448.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1)
      Source sequence(s)
      AL589879
      Consensus CDS
      CCDS49213.1
      UniProtKB/TrEMBL
      A0JLV3, Q8CBB6
      Related
      ENSMUSP00000089343.3, ENSMUST00000091749.4
      Conserved Domains (2) summary
      pfam00125
      Location:3 → 102
      Histone; Core histone H2A/H2B/H3/H4
      cl23830
      Location:12 → 125
      H2B; Histone H2B

    2. NM_001313880.1 → NP_001300809.1  H2b histone family, member A isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is intronless and contains a palindromic termination sequence instead of a polyA signal, compared to variant 1. It encodes isoform 2 which has a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AL589879
      Consensus CDS
      CCDS84010.1
      UniProtKB/Swiss-Prot
      P10853, Q5SZZ3
      UniProtKB/TrEMBL
      A0JLV3
      Related
      ENSMUSP00000106095.2, ENSMUST00000110469.2
      Conserved Domains (1) summary
      smart00427
      Location:28 → 124
      H2B; Histone H2B

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      21990582..21994369 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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