Prpsap2 phosphoribosyl pyrophosphate synthetase-associated protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prpsap2provided by MGI
Official Full Name: phosphoribosyl pyrophosphate synthetase-associated protein 2provided by MGI
Primary source: MGI:MGI:2384838
See related: Ensembl:ENSMUSG00000020528 AllianceGenome:MGI:2384838
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: PAP41; A230054F23Rik
Summary: Predicted to enable identical protein binding activity and ribose phosphate diphosphokinase activity. Acts upstream of or within bone development. Predicted to be part of ribose phosphate diphosphokinase complex. Predicted to be active in cytoplasm. Is expressed in central nervous system; ganglia; neural retina; and renal cortex. Orthologous to human PRPSAP2 (phosphoribosyl pyrophosphate synthetase associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 16.4), CNS E14 (RPKM 16.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.96 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (61620476..61652924, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (61729650..61762098, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236605

AA859332 (e-PCR)
- UniSTS:243919

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables ribose phosphate diphosphokinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in 5-phosphoribose 1-diphosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within bone development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in nucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in purine nucleotide biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of ribose phosphate diphosphokinase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ribose phosphate diphosphokinase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphoribosyl pyrophosphate synthase-associated protein 2

Names: 41 kDa phosphoribosypyrophosphate synthetase-associated protein; PRPP synthase-associated protein 2; PRPP synthetase-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164242.1 → NP_001157714.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a

See identical proteins and their annotated locations for NP_001157714.1

Status: VALIDATED

Source sequence(s)

AK038680, BY204265, BY550047

Consensus CDS

CCDS24819.1

UniProtKB/Swiss-Prot

Q8R574

UniProtKB/TrEMBL

Q5SWZ0, Q8BK37

Related

ENSMUSP00000126274.2, ENSMUST00000168115.8

Conserved Domains (2) summary

pfam13793
Location:20 → 138

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:179 → 363

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001164243.1 → NP_001157715.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform b

See identical proteins and their annotated locations for NP_001157715.1

Status: VALIDATED

Source sequence(s)

AK038680, BY204265, BY550047

UniProtKB/TrEMBL

Q05BD4

Related

ENSMUST00000151966.8

Conserved Domains (2) summary

pfam13793
Location:1 → 52

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:93 → 277

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001164244.1 → NP_001157716.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform b

See identical proteins and their annotated locations for NP_001157716.1

Status: VALIDATED

Source sequence(s)

AK038680, BY204265, BY550047

UniProtKB/TrEMBL

Q05BD4

Conserved Domains (2) summary

pfam13793
Location:1 → 52

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:93 → 277

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001364086.1 → NP_001351015.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a

Status: VALIDATED

Source sequence(s)

AL596209

Consensus CDS

CCDS24819.1

UniProtKB/Swiss-Prot

Q8R574

UniProtKB/TrEMBL

Q5SWZ0, Q8BK37

Conserved Domains (2) summary

pfam13793
Location:20 → 138

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:179 → 363

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001364087.1 → NP_001351016.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a

Status: VALIDATED

Source sequence(s)

AL596209

Consensus CDS

CCDS24819.1

UniProtKB/Swiss-Prot

Q8R574

UniProtKB/TrEMBL

Q5SWZ0, Q8BK37

Conserved Domains (2) summary

pfam13793
Location:20 → 138

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:179 → 363

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001364088.1 → NP_001351017.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform c

Status: VALIDATED

Source sequence(s)

AL596209

Conserved Domains (2) summary

pfam13793
Location:1 → 59

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:100 → 284

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_001364090.1 → NP_001351019.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform b

Status: VALIDATED

Source sequence(s)

AL596209

UniProtKB/TrEMBL

Q05BD4

Conserved Domains (2) summary

pfam13793
Location:1 → 52

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:93 → 277

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
NM_144806.2 → NP_659055.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform a

See identical proteins and their annotated locations for NP_659055.1

Status: VALIDATED

Source sequence(s)

AK038680, BY204265, BY550047

Consensus CDS

CCDS24819.1

UniProtKB/Swiss-Prot

Q8R574

UniProtKB/TrEMBL

Q5SWZ0, Q8BK37

Related

ENSMUSP00000004955.8, ENSMUST00000004955.14

Conserved Domains (2) summary

pfam13793
Location:20 → 138

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:179 → 363

Pribosyl_synth; Phosphoribosyl synthetase-associated domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

61620476..61652924 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030245755.2 → XP_030101615.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1

UniProtKB/Swiss-Prot

Q8R574

UniProtKB/TrEMBL

Q5SWZ0, Q8BK37

Conserved Domains (2) summary

pfam13793
Location:20 → 138

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:179 → 363

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
XM_030245756.2 → XP_030101616.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

Conserved Domains (2) summary

pfam13793
Location:1 → 59

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:100 → 284

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
XM_036156496.1 → XP_036012389.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

Conserved Domains (2) summary

pfam13793
Location:1 → 59

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:100 → 284

Pribosyl_synth; Phosphoribosyl synthetase-associated domain
XM_036156497.1 → XP_036012390.1 phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X2

Conserved Domains (2) summary

pfam13793
Location:1 → 59

Pribosyltran_N; N-terminal domain of ribose phosphate pyrophosphokinase

pfam14572
Location:100 → 284

Pribosyl_synth; Phosphoribosyl synthetase-associated domain