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    Rnf123 ring finger protein 123 [ Mus musculus (house mouse) ]

    Gene ID: 84585, updated on 21-May-2024

    Summary

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    Official Symbol
    Rnf123provided by MGI
    Official Full Name
    ring finger protein 123provided by MGI
    Primary source
    MGI:MGI:2148796
    See related
    Ensembl:ENSMUSG00000041528 AllianceGenome:MGI:2148796
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kpc1
    Summary
    Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Is expressed in liver. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14.5 (RPKM 28.3), spleen adult (RPKM 26.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf123 in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107928869..107957183, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108051672..108080352, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930535L15 gene Neighboring gene cadherin-related family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene inositol hexaphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2305 Neighboring gene STARR-positive B cell enhancer ABC_E6803 Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene STARR-positive B cell enhancer ABC_E2914 Neighboring gene acylpeptide hydrolase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection. Miyasaka Y, et al. Parasitol Int, 2022 Jun. PMID 35063657
    2. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation. Tashiro R, et al. J Cell Physiol, 2021 Nov. PMID 33973242
    3. Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Susaki E, et al. Proc Natl Acad Sci U S A, 2009 Mar 31. PMID 19276117, Free PMC Article
    4. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
    5. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Lu Y, et al. Mol Cell Biol, 2009 Jan. PMID 19015242, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection.
      Title: E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection.
    2. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.
      Title: Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5)  1 citation
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein maturation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF123
    Names
    RING-type E3 ubiquitin transferase RNF123
    kip1 ubiquitination-promoting complex protein 1
    ubiquitin ligase
    NP_001298081.1
    NP_001408507.1
    NP_001408508.1
    NP_115932.1
    XP_006511941.1
    XP_006511942.1
    XP_030100604.1
    XP_030100605.1
    XP_036011311.1
    XP_036011312.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311152.2 → NP_001298081.1  E3 ubiquitin-protein ligase RNF123 isoform 1

      See identical proteins and their annotated locations for NP_001298081.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC137678
      Consensus CDS
      CCDS81072.1
      UniProtKB/TrEMBL
      Q05CH9
      Related
      ENSMUSP00000125745.2, ENSMUST00000162355.8
      Conserved Domains (2) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1258 → 1298
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    2. NM_001421578.1 → NP_001408507.1  E3 ubiquitin-protein ligase RNF123 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC137678
      Related
      ENSMUST00000159136.8

    3. NM_001421579.1 → NP_001408508.1  E3 ubiquitin-protein ligase RNF123 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC137678
      UniProtKB/Swiss-Prot
      Q5XPI3, Q6PGE0

    4. NM_032543.3 → NP_115932.1  E3 ubiquitin-protein ligase RNF123 isoform 2

      See identical proteins and their annotated locations for NP_115932.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
      Source sequence(s)
      AC137678
      Consensus CDS
      CCDS52922.1
      UniProtKB/Swiss-Prot
      Q5XPI3, Q6PGE0
      UniProtKB/TrEMBL
      Q05CH9
      Related
      ENSMUSP00000125495.3, ENSMUST00000160649.9
      Conserved Domains (2) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1252 → 1292
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    RNA

    1. NR_185313.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137678

    2. NR_185314.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC137678

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107928869..107957183 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511879.5 → XP_006511942.1  E3 ubiquitin-protein ligase RNF123 isoform X1

      See identical proteins and their annotated locations for XP_006511942.1

      UniProtKB/TrEMBL
      Q05CH9
      Related
      ENSMUST00000161673.8
      Conserved Domains (2) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1258 → 1298
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    2. XM_006511878.4 → XP_006511941.1  E3 ubiquitin-protein ligase RNF123 isoform X1

      See identical proteins and their annotated locations for XP_006511941.1

      UniProtKB/TrEMBL
      Q05CH9
      Conserved Domains (2) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1258 → 1298
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    3. XM_036155418.1 → XP_036011311.1  E3 ubiquitin-protein ligase RNF123 isoform X2

      UniProtKB/TrEMBL
      Q05CH9
      Conserved Domains (2) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
      cd16541
      Location:1254 → 1294
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    4. XM_030244744.2 → XP_030100604.1  E3 ubiquitin-protein ligase RNF123 isoform X5

      Conserved Domains (1) summary
      cd16541
      Location:877 → 917
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    5. XM_030244745.2 → XP_030100605.1  E3 ubiquitin-protein ligase RNF123 isoform X6

      Conserved Domains (1) summary
      cd16541
      Location:871 → 911
      RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

    6. XM_036155419.1 → XP_036011312.1  E3 ubiquitin-protein ligase RNF123 isoform X4

      UniProtKB/TrEMBL
      Q05CH9
      Conserved Domains (1) summary
      cd12882
      Location:123 → 250
      SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

    RNA

    1. XR_004935615.1 RNA Sequence

    2. XR_004935614.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XPI3.1 GenPept UniProtKB/Swiss-Prot:Q5XPI3

    Gene LinkOut

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