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    Vmn2r43 vomeronasal 2, receptor 43 [ Mus musculus (house mouse) ]

    Gene ID: 381838, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Vmn2r43provided by MGI
    Official Full Name
    vomeronasal 2, receptor 43provided by MGI
    Primary source
    MGI:MGI:3037819
    See related
    Ensembl:ENSMUSG00000053720 AllianceGenome:MGI:3037819
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1961; EC2-V2R
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vmn2r43 in Genome Data Viewer
    Location:
    7 A1; 7 5.76 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (8247347..8263598, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (8244348..8260599, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene vomeronasal 2, receptor 41 Neighboring gene vomeronasal 2, receptor 42 Neighboring gene predicted gene 3654 Neighboring gene vomeronasal 2, receptor, pseudogene 45

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Functional expression of murine V2R pheromone receptors involves selective association with the M10 and M1 families of MHC class Ib molecules. Loconto J, et al. Cell, 2003 Mar 7. PMID 12628182
    2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2, receptor 43
    Names
    EC2-V2R pheromone receptor
    vomeronasal receptor Vmn2r43

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198961.3 → NP_945199.1  vomeronasal 2, receptor 43 precursor

      See identical proteins and their annotated locations for NP_945199.1

      Status: VALIDATED

      Source sequence(s)
      AC165963, AC188454
      Consensus CDS
      CCDS57484.1
      UniProtKB/TrEMBL
      K7N652, Q80Z08
      Related
      ENSMUSP00000069647.5, ENSMUST00000066317.5
      Conserved Domains (4) summary
      pfam00003
      Location:583 → 817
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:75 → 429
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:497 → 548
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cl10011
      Location:39 → 487
      Periplasmic_Binding_Protein_Type_1; Type 1 periplasmic binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      8247347..8263598 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017322322.1 → XP_017177811.1  vomeronasal 2, receptor 43 isoform X1

      UniProtKB/TrEMBL
      K7N652
      Conserved Domains (3) summary
      cd15283
      Location:585 → 836
      7tmC_V2R_pheromone; vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors
      pfam07562
      Location:512 → 565
      NCD3G; Nine Cysteines Domain of family 3 GPCR
      cd06365
      Location:43 → 503
      PBP1_pheromone_receptor; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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