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    OPI10 Opi10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854125, updated on 17-May-2024

    Summary

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    Gene symbol
    OPI10
    Gene description
    Opi10p
    Primary source
    FungiDB:YOL032W
    Locus tag
    YOL032W
    See related
    SGD:S000005392; AllianceGenome:SGD:S000005392; VEuPathDB:YOL032W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable nuclear import signal receptor activity. Involved in inositol metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 13. Orthologous to human HIKESHI (heat shock protein nuclear import factor hikeshi). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OPI10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (265429..266169)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene DNA repair ATPase SMC5 Neighboring gene glutamate--tRNA ligase MSE1 Neighboring gene Sil1p Neighboring gene 1,3-beta-glucanosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of the DNA sequence of a 34,038 bp region on the left arm of yeast chromosome XV. Rad MR, et al. Yeast, 1997 Mar 15. PMID 9090058
    2. Genomic analysis of the Opi- phenotype. Hancock LC, et al. Genetics, 2006 Jun. PMID 16582425, Free PMC Article
    3. J domain co-chaperone specificity defines the role of BiP during protein translocation. Vembar SS, et al. J Biol Chem, 2010 Jul 16. PMID 20430885, Free PMC Article
    4. A role for the budding yeast separase, Esp1, in Ty1 element retrotransposition. Ho KL, et al. PLoS Genet, 2015 Mar. PMID 25822502, Free PMC Article
    5. Functional characterisation of long intergenic non-coding RNAs through genetic interaction profiling in Saccharomyces cerevisiae. Kyriakou D, et al. BMC Biol, 2016 Dec 7. PMID 27927215, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in inositol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Opi10p
    NP_014610.1
    • Protein with a possible role in phospholipid biosynthesis; null mutant displays an inositol-excreting phenotype that is suppressed by exogenous choline; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      265429..266169
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183286.1 → NP_014610.1  TPA: Opi10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014610.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W233, Q08202
      UniProtKB/TrEMBL
      A0A6A5Q3P9, A6ZNH5, B3LJ25, B5VRL8, C7GK02, C8ZHT2, G2WMJ9, N1P2S8
      Conserved Domains (1) summary
      pfam05603
      Location:1 → 240
      DUF775; Protein of unknown function (DUF775)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08202.1

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