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    PMI40 mannose-6-phosphate isomerase PMI40 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856720, updated on 17-May-2024

    Summary

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    Gene symbol
    PMI40
    Gene description
    mannose-6-phosphate isomerase PMI40
    Primary source
    FungiDB:YER003C
    Locus tag
    YER003C
    See related
    SGD:S000000805; AllianceGenome:SGD:S000000805; VEuPathDB:YER003C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mannose-6-phosphate isomerase activity. Involved in GDP-mannose biosynthetic process; cell wall mannoprotein biosynthetic process; and protein glycosylation. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in carbohydrate metabolic disorder and congenital disorder of glycosylation Ib. Orthologous to human MPI (mannose phosphate isomerase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PMI40 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    2
    Sequence:
    Chromosome: V; NC_001137.3 (157736..159118, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene alpha-1,3-mannosyltransferase MNN1 Neighboring gene Nop16p Neighboring gene Fmp52p Neighboring gene apyrase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Polarizable water networks in ligand-metalloprotein recognition. Impact on the relative complexation energies of Zn-dependent phosphomannose isomerase with D-mannose 6-phosphate surrogates. Gresh N, et al. J Phys Chem B, 2011 Jun 30. PMID 21650197
    2. Excess mannose limits the growth of phosphomannose isomerase PMI40 deletion strain of Saccharomyces cerevisiae. Pitkänen JP, et al. J Biol Chem, 2004 Dec 31. PMID 15520001
    3. Inhibition of type I and type II phosphomannose isomerases by the reaction intermediate analogue 5-phospho-D-arabinonohydroxamic acid supports a catalytic role for the metal cofactor. Roux C, et al. Biochemistry, 2004 Mar 16. PMID 15005628
    4. Inhibition of Saccharomyces cerevisiae phosphomannose isomerase by the NO-donor S-nitroso-acetyl-penicillamine. Salvati L, et al. J Enzyme Inhib, 2001. PMID 11697049
    5. Phosphomannose isomerase from Saccharomyces cerevisiae contains two inhibitory metal ion binding sites. Wells TN, et al. Biochemistry, 1993 Feb 9. PMID 8448139

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the phosphomannose isomerase-deleted strain is viable only if fed with extracellular mannose and glucose
      Title: Excess mannose limits the growth of phosphomannose isomerase PMI40 deletion strain of Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose-6-phosphate isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mannose-6-phosphate isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mannose-6-phosphate isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in GDP-mannose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GDP-mannose biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GDP-mannose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    mannose-6-phosphate isomerase PMI40
    NP_010918.1
    • Mannose-6-phosphate isomerase; catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      157736..159118 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178894.1 → NP_010918.1  TPA: mannose-6-phosphate isomerase PMI40 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010918.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLP9, P29952
      UniProtKB/TrEMBL
      A6ZQU9, B3LS14, C8Z701, G2WCN3, N1PA80
      Conserved Domains (2) summary
      pfam01238
      Location:5 → 392
      PMI_typeI; Phosphomannose isomerase type I
      cl40423
      Location:377 → 418
      cupin_RmlC-like; RmlC-like cupin superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29952.4

    Gene LinkOut

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