PRE1 proteasome core particle subunit beta 4 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856731, updated on 9-Jun-2024

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Summary

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Gene symbol: PRE1
Gene description: proteasome core particle subunit beta 4
Primary source: FungiDB:YER012W
Locus tag: YER012W
See related: SGD:S000000814; AllianceGenome:SGD:S000000814; VEuPathDB:YER012W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables endopeptidase activator activity. Involved in proteasomal ubiquitin-independent protein catabolic process and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and nucleus. Part of proteasome core complex, beta-subunit complex. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See PRE1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_001137.3 (177835..178431)

Chromosome V - NC_001137.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001137.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables endopeptidase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in proteasomal protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasomal ubiquitin-independent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasomal ubiquitin-independent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: proteasome core particle subunit beta 4

NP_010928.1

Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001137.3 Reference assembly

Range

177835..178431

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001178903.1 → NP_010928.1 TPA: proteasome core particle subunit beta 4 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010928.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLQ9, P22141

UniProtKB/TrEMBL

A0A6A5Q0W2, A6ZQV9, B3LS24, B5VHE3, C7GKJ0, C8Z712, G2WCP3, N1PA82

Conserved Domains (1) summary

cd03758
Location:1 → 194

proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

Nucleotide		Protein
Heading	Accession and Version	Protein

Protein Accession	Links
Protein Accession	GenPept Link	UniProtKB Link
1G65_J.1
1G65_X.1
3JCO_6.1
3JCO_k.1
3JCP_6.1
3JCP_k.1
3OEU_J.1
3OEU_X.1
3OEV_J.1
3OEV_X.1
3SDI_J.1
3SDI_X.1
3SDK_J.1
3SDK_X.1
3SHJ_J.1
3SHJ_X.1
3TDD_J.1
3TDD_X.1
3UN4_J.1
3UN4_X.1
3UN8_J.1
3UN8_X.1
4EU2_K.1
4EU2_Y.1
4FZC_J.1
4FZC_X.1
4FZG_J.1
4FZG_X.1
4G4S_K.1
4GK7_J.1
4GK7_X.1
4HRC_J.1
4HRC_X.1
4HRD_J.1
4HRD_X.1
4JSQ_J.1
4JSQ_X.1
4JSU_J.1
4JSU_X.1
4JT0_J.1
4JT0_X.1
4LTC_J.1
4LTC_X.1
4NNN_J.1
4NNN_X.1
4NNW_J.1
4NNW_X.1
4NO1_J.1
4NO1_X.1
4NO6_J.1
4NO6_X.1
4NO8_J.1
4NO8_X.1
4NO9_J.1
4NO9_X.1
4Q1S_J.1
4Q1S_X.1
4QBY_J.1
4QBY_X.1
4QLQ_J.1
4QLQ_X.1
4QLS_J.1
4QLS_X.1
4QLT_J.1
4QLT_X.1
4QLU_J.1
4QLU_X.1
4QLV_J.1
4QLV_X.1
4QUX_J.1
4QUX_X.1
4QUY_J.1
4QUY_X.1
4QV0_J.1
4QV0_X.1
4QV1_J.1
4QV1_X.1
4QV3_J.1
4QV3_X.1
4QV4_J.1
4QV4_X.1
4QV5_J.1
4QV5_X.1
4QV6_J.1
4QV6_X.1
4QV7_J.1
4QV7_X.1
4QV8_J.1
4QV8_X.1
4QV9_J.1
4QV9_X.1
4QVL_J.1
4QVL_X.1
4QVM_J.1
4QVM_X.1
4QVN_J.1
4QVN_X.1
4QVP_J.1
4QVP_X.1
4QVQ_J.1
4QVQ_X.1
4QVV_J.1
4QVV_X.1
4QVW_J.1
4QVW_X.1
4QVY_J.1
4QVY_X.1
4QW0_J.1
4QW0_X.1
4QW1_J.1
4QW1_X.1
4QW3_J.1
4QW3_X.1
4QW4_J.1
4QW4_X.1
4QW5_J.1
4QW5_X.1
4QW6_J.1
4QW6_X.1
4QW7_J.1
4QW7_X.1
4QWF_J.1
4QWF_X.1
4QWG_J.1
4QWG_X.1
4QWI_J.1
4QWI_X.1
4QWJ_J.1
4QWJ_X.1
4QWK_J.1
4QWK_X.1
4QWL_J.1
4QWL_X.1
4QWR_J.1
4QWR_X.1
4QWS_J.1
4QWS_X.1
4QWU_J.1
4QWU_X.1
4QWX_J.1
4QWX_X.1
4QXJ_J.1
4QXJ_X.1
4QZ0_J.1
4QZ0_X.1
4QZ1_J.1
4QZ1_X.1
4QZ2_J.1
4QZ2_X.1
4QZ3_J.1
4QZ3_X.1
4QZ4_J.1
4QZ4_X.1
4QZ5_J.1
4QZ5_X.1
4QZ6_J.1
4QZ6_X.1
4QZ7_J.1
4QZ7_X.1
4QZW_J.1
4QZW_X.1
4QZX_J.1
4QZX_X.1
4QZZ_J.1
4QZZ_X.1
4R00_J.1
4R00_X.1
4R02_J.1
4R02_X.1
4R17_J.1
4R17_X.1
4R18_J.1
4R18_X.1
4RUR_J.1
4RUR_X.1
4X6Z_K.1
4X6Z_Y.1
4Y69_J.1
4Y69_X.1
4Y6A_J.1
4Y6A_X.1
4Y6V_J.1
4Y6V_X.1
4Y6Z_J.1
4Y6Z_X.1
4Y70_J.1
4Y70_X.1
4Y74_J.1
4Y74_X.1
4Y75_J.1
4Y75_X.1
4Y77_J.1
4Y77_X.1
4Y78_J.1
4Y78_X.1
4Y7W_J.1
4Y7W_X.1
4Y7X_J.1
4Y7X_X.1
4Y7Y_J.1
4Y7Y_X.1
4Y80_J.1
4Y80_X.1
4Y81_J.1
4Y81_X.1
4Y82_J.1
4Y82_X.1
4Y84_J.1
4Y84_X.1
4Y8G_J.1
4Y8G_X.1
4Y8H_J.1
4Y8H_X.1
4Y8I_J.1
4Y8I_X.1
4Y8J_J.1
4Y8J_X.1
4Y8K_J.1
4Y8K_X.1
4Y8L_J.1
4Y8L_X.1
4Y8M_J.1
4Y8M_X.1
4Y8N_J.1
4Y8N_X.1
4Y8O_J.1
4Y8O_X.1
4Y8P_J.1
4Y8P_X.1
4Y8Q_J.1
4Y8Q_X.1
4Y8R_J.1
4Y8R_X.1
4Y8S_J.1
4Y8S_X.1
4Y8T_J.1
4Y8T_X.1
4Y8U_J.1
4Y8U_X.1
4Y9Y_J.1
4Y9Y_X.1
4Y9Z_J.1
4Y9Z_X.1
4YA0_J.1
4YA0_X.1
4YA1_J.1
4YA1_X.1
4YA2_J.1
4YA2_X.1
4YA3_J.1
4YA3_X.1
4YA4_J.1
4YA4_X.1
4YA5_J.1
4YA5_X.1
4YA7_J.1
4YA7_X.1
4YA9_J.1
4YA9_X.1
4Z1L_J.1
4Z1L_X.1
5BOU_J.1
5BOU_X.1
5BXL_J.1
5BXL_X.1
5BXN_J.1
5BXN_X.1
5CGF_J.1
5CGF_X.1
5CGG_J.1
5CGG_X.1
5CGH_J.1
5CGH_X.1
5CGI_J.1
5CGI_X.1
5CZ4_J.1
5CZ4_X.1
5CZ5_J.1
5CZ5_X.1
5CZ6_J.1
5CZ6_X.1
5CZ7_J.1
5CZ7_X.1
5CZ8_J.1
5CZ8_X.1
5CZ9_J.1
5CZ9_X.1
5CZA_J.1
5CZA_X.1
5D0S_J.1
5D0S_X.1
5D0T_J.1
5D0T_X.1
5D0V_J.1
5D0V_X.1
5D0W_J.1
5D0W_X.1
5D0X_J.1
5D0X_X.1
5D0Z_J.1
5D0Z_X.1
5DKI_J.1
5DKI_X.1
5DKJ_J.1
5DKJ_X.1
5FG7_J.1
5FG7_X.1
5FG9_J.1
5FG9_X.1
5FGA_J.1
5FGA_X.1
5FGD_J.1
5FGD_X.1
5FGE_J.1
5FGE_X.1
5FGF_J.1
5FGF_X.1
5FGG_J.1
5FGG_X.1
5FGH_J.1
5FGH_X.1
5FGI_J.1
5FGI_X.1
5FHS_J.1
5FHS_X.1
5JHR_J.1
5JHR_X.1
5JHS_J.1
5JHS_X.1
5L52_J.1
5L52_X.1
5L54_J.1
5L54_X.1
5L55_J.1
5L55_X.1
5L5A_J.1
5L5A_X.1
5L5B_J.1
5L5B_X.1
5L5D_J.1
5L5D_X.1
5L5E_J.1
5L5E_X.1
5L5F_J.1
5L5F_X.1
5L5H_J.1
5L5H_X.1
5L5I_J.1
5L5I_X.1
5L5J_J.1
5L5J_X.1
5L5O_J.1
5L5O_X.1
5L5P_J.1
5L5P_X.1
5L5Q_J.1
5L5Q_X.1
5L5R_J.1
5L5R_X.1
5L5S_J.1
5L5S_X.1
5L5T_J.1
5L5T_X.1
5L5U_J.1
5L5U_X.1
5L5V_J.1
5L5V_X.1
5L5W_J.1
5L5W_X.1
5L5X_J.1
5L5X_X.1
5L5Y_J.1
5L5Y_X.1
5L5Z_J.1
5L5Z_X.1
5L60_J.1
5L60_X.1
5L61_J.1
5L61_X.1
5L62_J.1
5L62_X.1
5L63_J.1
5L63_X.1
5L64_J.1
5L64_X.1
5L65_J.1
5L65_X.1
5L66_J.1
5L66_X.1
5L67_J.1
5L67_X.1
5L68_J.1
5L68_X.1
5L69_J.1
5L69_X.1
5L6A_J.1
5L6A_X.1
5L6B_J.1
5L6B_X.1
5L6C_J.1
5L6C_X.1
5LAI_J.1
5LAI_X.1
5LAJ_J.1
5LAJ_X.1
5LTT_J.1
5LTT_X.1
5M2B_J.1
5M2B_X.1
5MP9_4.1
5MP9_k.1
5MPA_4.1
5MPA_k.1
5MPB_4.1
5MPB_k.1
5MPC_4.1
5MPC_k.1
5NIF_K.1
5NIF_Y.1
5WVI_4.1
5WVI_g.1
5WVK_4.1
5WVK_g.1
6EF3_4.1
6G7F_J.1
6G7F_X.1
6G8M_J.1
6G8M_X.1
6G8N_J.1
6G8N_X.1
6GOP_J.1
6GOP_X.1
6H39_J.1
6H39_X.1
6HTB_J.1
6HTB_X.1
6HTC_J.1
6HTC_X.1
6HTD_J.1
6HTD_X.1
6HTP_J.1
6HTP_X.1
6HTR_J.1
6HTR_X.1
6HUB_J.1
6HUB_X.1
6HUC_J.1
6HUC_X.1
6HUQ_J.1
6HUQ_X.1
6HUU_J.1
6HUU_X.1
6HUV_J.1
6HUV_X.1
6HV3_J.1
6HV3_X.1
6HV4_J.1
6HV4_X.1
6HV5_J.1
6HV5_X.1
6HV7_J.1
6HV7_X.1
6HVA_J.1
6HVA_X.1
6HVR_J.1
6HVR_X.1
6HVS_J.1
6HVS_X.1
6HVT_J.1
6HVT_X.1
6HVU_J.1
6HVU_X.1
6HVV_J.1
6HVV_X.1
6HVW_J.1
6HVW_X.1
6HVX_J.1
6HVX_X.1
6HVY_J.1
6HVY_X.1
6HW0_J.1
6HW0_X.1
6HW3_J.1
6HW3_X.1
6HW4_J.1
6HW4_X.1
6HW5_J.1
6HW5_X.1
6HW6_J.1
6HW6_X.1
6HW7_J.1
6HW7_X.1
6HW8_J.1
6HW8_X.1
6HW9_J.1
6HW9_X.1
6HWA_J.1
6HWA_X.1
6HWB_J.1
6HWB_X.1
6HWC_J.1
6HWC_X.1
6HWD_J.1
6HWD_X.1
6HWE_J.1
6HWE_X.1
6HWF_J.1
6HWF_X.1
6J2C_4.1
6J2C_g.1
6J2N_4.1
6J2N_g.1
6J2Q_4.1
6J2Q_g.1
6J2X_4.1
6J2X_g.1
6J30_4.1
6J30_g.1
6ZOU_J.1
6ZOU_X.1
6ZP6_J.1
6ZP6_X.1
6ZP8_J.1
6ZP8_X.1
7LS6_K.1
7LSX_K.1
P22141.2