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    ARG1 argininosuccinate synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854096, updated on 17-May-2024

    Summary

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    Gene symbol
    ARG1
    Gene description
    argininosuccinate synthase
    Primary source
    FungiDB:YOL058W
    Locus tag
    YOL058W
    See related
    SGD:S000005419; AllianceGenome:SGD:S000005419; VEuPathDB:YOL058W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ARG10
    Summary
    Enables argininosuccinate synthase activity. Involved in arginine biosynthetic process. Located in cytosol. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARG1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (219211..220473)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Mam3p Neighboring gene glycerol-3-phosphate dehydrogenase (NAD(+)) GPD2 Neighboring gene dipeptidyl-peptidase III Neighboring gene phosphoglycerate mutase family protein GPM3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic mapping of arg1 and arg8 in Saccharomyces cerevisiae by trisomic analysis combined with interallelic complementation. Hilger F, et al. J Bacteriol, 1980 Jan. PMID 6986360, Free PMC Article
    2. Yeast argininosuccinate synthetase. Purification; structural and kinetic properties. Hilger F, et al. Eur J Biochem, 1979 Feb 15. PMID 35347
    3. Two functional motifs define the interaction, internalization and toxicity of the cell-penetrating antifungal peptide PAF26 on fungal cells. Muñoz A, et al. PLoS One, 2013. PMID 23349973, Free PMC Article
    4. Sensitivity of Saccharomyces cerevisiae to the cell-penetrating antifungal peptide PAF26 correlates with endogenous nitric oxide (NO) production. Carmona L, et al. Biochem Biophys Res Commun, 2012 Jan 6. PMID 22120633
    5. Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae. Crabeel M, et al. Yeast, 1995 Nov. PMID 8585320

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. By promoting histone H2B lysine 123 ubiquitylation, Paf1 represses the ARG1 gene by negatively affecting Gcn4 occupancy at the promoter.
      Title: Paf1 restricts Gcn4 occupancy and antisense transcription at the ARG1 promoter.
    2. Mcm1p binding positively regulate ARG1 transcription and cell growth in the absence of arginine and Gcn4p.
      Title: Mcm1p binding sites in the ARG1 promoter positively regulate ARG1 transcription and S. cerevisiae growth in the absence of arginine and Gcn4p.
    3. Mcm1p contributes to active transcription at the ARG1 promoter by increasing the binding of the activator Gcn4p and by recruiting the co-activator complex SWI/SNF at ARG1 under Gcn4p-induced conditions.
      Title: Mcm1p binding sites in ARG1 positively regulate Gcn4p binding and SWI/SNF recruitment.
    4. Gcn4p stimulates binding of Cyc8p/Tup1p at the 3' end of the ARG1 gene.
      Title: Activator Gcn4p and Cyc8p/Tup1p are interdependent for promoter occupancy at ARG1 in vivo.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables argininosuccinate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables argininosuccinate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables argininosuccinate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in arginine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in arginine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in arginine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in argininosuccinate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in urea cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    argininosuccinate synthase
    NP_014583.2
    • Argininosuccinate synthetase; catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      219211..220473
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183313.2 → NP_014583.2  TPA: argininosuccinate synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014583.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W209, P22768
      UniProtKB/TrEMBL
      A0A182B5T6, A0A6A5Q367, A6ZNF2, B3LJ01, C7GK25, C8ZHQ5, G2WMH6, N1P2Q7
      Conserved Domains (1) summary
      pfam00764
      Location:7 → 406
      Arginosuc_synth; Arginosuccinate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22768.3

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