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    INA17 Ina17p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856005, updated on 17-May-2024

    Summary

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    Gene symbol
    INA17
    Gene description
    Ina17p
    Primary source
    FungiDB:YPL099C
    Locus tag
    YPL099C
    See related
    SGD:S000006020; AllianceGenome:SGD:S000006020; VEuPathDB:YPL099C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    AIM43; FMP14
    Summary
    Involved in mitochondrial proton-transporting ATP synthase complex assembly. Is intrinsic component of mitochondrial inner membrane. Part of INA complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See INA17 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (363520..364068, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Elongator subunit ELP4 Neighboring gene Atg21p Neighboring gene Mgr2p Neighboring gene tyrosine--tRNA ligase MSY1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase. Lytovchenko O, et al. EMBO J, 2014 Aug 1. PMID 24942160, Free PMC Article
    2. Transfer of the Septin Ring to Cytokinetic Remnants in ER Stress Directs Age-Sensitive Cell-Cycle Re-entry. Chao JT, et al. Dev Cell, 2019 Oct 21. PMID 31564614, Free PMC Article
    3. A genomic analysis of chronological longevity factors in budding yeast. Burtner CR, et al. Cell Cycle, 2011 May 1. PMID 21447998, Free PMC Article
    4. Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. Hess DC, et al. PLoS Genet, 2009 Mar. PMID 19300474, Free PMC Article
    5. INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules. Naumenko N, et al. Nat Commun, 2017 Nov 1. PMID 29093463, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. INAC maintains assembly intermediates of the F1 F0-ATP synthase in a primed state for the terminal assembly step-motor module formation.
      Title: INA complex liaises the F(1)F(o)-ATP synthase membrane motor modules.
    2. INA22 and INA17 complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.
      Title: The INA complex facilitates assembly of the peripheral stalk of the mitochondrial F1Fo-ATP synthase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in mitochondrial proton-transporting ATP synthase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of INA complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of INA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ina17p
    NP_015226.1
    • F1F0 ATPase synthase peripheral stalk assembly factor; subunit of the matrix-exposed inner mitochondrial membrane localized INA complex (Ina22p-Ina17p) involved in assembly of the F1F0 peripheral stalk; co-purifies with Ina22p and ATP synthase subunits; null mutant displays elevated frequency of mitochondrial genome loss and has a respiratory growth defect

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      363520..364068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183913.1 → NP_015226.1  TPA: Ina17p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015226.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZWF1, B3LKX3, B5VT63, C8ZIT1, D6W3R7, Q02888
      UniProtKB/TrEMBL
      A0A7I9C501, N1NVW8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02888.1

    Gene LinkOut

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