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    Emc7 ER membrane protein complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 73024, updated on 20-Apr-2024

    Summary

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    Official Symbol
    Emc7provided by MGI
    Official Full Name
    ER membrane protein complex subunit 7provided by MGI
    Primary source
    MGI:MGI:1920274
    See related
    Ensembl:ENSMUSG00000055943 AllianceGenome:MGI:1920274
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF3; c11orf3; 2900064A13Rik
    Summary
    Predicted to enable carbohydrate binding activity. Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Is expressed in central nervous system; liver; lung; retina nuclear layer; and skeletal muscle. Orthologous to human EMC7 (ER membrane protein complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 15.8), placenta adult (RPKM 15.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Emc7 in Genome Data Viewer
    Location:
    2 E3; 2 57.02 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (112285332..112302507)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (112455014..112472163)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 12, member 6 Neighboring gene STARR-positive B cell enhancer mm9_chr2:112219168-112219469 Neighboring gene STARR-positive B cell enhancer ABC_E5959 Neighboring gene katanin p80 subunit B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E3389 Neighboring gene STARR-positive B cell enhancer ABC_E11150 Neighboring gene ER membrane protein complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E4487 Neighboring gene STARR-seq mESC enhancer starr_05388 Neighboring gene cholinergic receptor, muscarinic 5 Neighboring gene predicted gene, 22676 Neighboring gene apoptosis, caspase activation inhibitor Neighboring gene STARR-positive B cell enhancer mm9_chr2:112443695-112443995 Neighboring gene STARR-seq mESC enhancer starr_05389 Neighboring gene STARR-seq mESC enhancer starr_05390 Neighboring gene ryanodine receptor 3 Neighboring gene STARR-seq mESC enhancer starr_05392 Neighboring gene STARR-seq mESC enhancer starr_05393 Neighboring gene STARR-seq mESC enhancer starr_05394

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Characterization of five novel human genes in the 11q13-q22 region. O'Brien KP, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873569
    2. EMC3 coordinates surfactant protein and lipid homeostasis required for respiration. Tang X, et al. J Clin Invest, 2017 Dec 1. PMID 29083321, Free PMC Article
    3. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
    4. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC144286, MGC144287

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tail-anchored membrane protein insertion into ER membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7
    Names
    UPF0480 protein C15orf24 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133749.2 → NP_598510.1  endoplasmic reticulum membrane protein complex subunit 7 precursor

      See identical proteins and their annotated locations for NP_598510.1

      Status: PROVISIONAL

      Source sequence(s)
      AL683897, AL731840
      Consensus CDS
      CCDS16555.1
      UniProtKB/Swiss-Prot
      Q9EP72
      UniProtKB/TrEMBL
      Q14C26
      Related
      ENSMUSP00000068610.6, ENSMUST00000069747.6
      Conserved Domains (1) summary
      pfam09430
      Location:56 → 167
      DUF2012; Protein of unknown function (DUF2012)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      112285332..112302507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500254.5 → XP_006500317.1  ER membrane protein complex subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006500317.1

      Conserved Domains (1) summary
      pfam09430
      Location:6 → 95
      DUF2012; Protein of unknown function (DUF2012)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EP72.1 GenPept UniProtKB/Swiss-Prot:Q9EP72

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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