Pdcl3 phosducin-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pdcl3provided by MGI
Official Full Name: phosducin-like 3provided by MGI
Primary source: MGI:MGI:1916083
See related: Ensembl:ENSMUSG00000026078 AllianceGenome:MGI:1916083
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Viaf1; 1110061A19Rik
Summary: Enables vascular endothelial growth factor receptor 2 binding activity. Involved in angiogenesis and positive regulation of gene expression. Located in cytoplasm. Part of protein-containing complex. Orthologous to human PDCL3 (phosducin like 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 53.0), CNS E11.5 (RPKM 29.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 B; 1 17.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (39026895..39036317)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (38987814..38997236)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results have shown that PhLP2A interacts with Hsp90 and exhibits molecular chaperone activity toward denatured proteins.
Title: Interaction of a Novel Chaperone PhLP2A With the Heat Shock Protein Hsp90.
The data provide new insights for the chaperone function of PDCL3 in angiogenesis and the roles of hypoxia and N-terminal methionine acetylation in PDCL3 expression and its effect on VEGFR-2.
Title: Hypoxia-induced expression of phosducin-like 3 regulates expression of VEGFR-2 and promotes angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables vascular endothelial growth factor receptor 2 binding	IBA Inferred from Biological aspect of Ancestor more info
enables vascular endothelial growth factor receptor 2 binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to heat	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinucleolar compartment	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phosducin-like protein 3

Names: IAP-associated factor VIAF1; VIAF-1; viral IAP-associated factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026850.4 → NP_081126.2 phosducin-like protein 3

See identical proteins and their annotated locations for NP_081126.2

Status: PROVISIONAL

Source sequence(s)

AC140367

Consensus CDS

CCDS14903.1

UniProtKB/Swiss-Prot

Q3TH06, Q8BVF2, Q99JX2, Q9D0W3

Related

ENSMUSP00000027247.6, ENSMUST00000027247.11

Conserved Domains (1) summary

cd02988
Location:8 → 203

Phd_like_VIAF; Phosducin (Phd)-like family, Viral inhibitor of apoptosis (IAP)-associated factor (VIAF) subfamily; VIAF is a Phd-like protein that functions in caspase activation during apoptosis. It was identified as an IAP binding protein through a screen of a human ...