Ip6k1 inositol hexaphosphate kinase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ip6k1provided by MGI
Official Full Name: inositol hexaphosphate kinase 1provided by MGI
Primary source: MGI:MGI:1351633
See related: Ensembl:ENSMUSG00000032594 AllianceGenome:MGI:1351633
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ihpk1; InsP6; Itpk6; InsP6k1; 1200016D08Rik
Summary: Predicted to enable inositol hexakisphosphate kinase activity. Involved in negative regulation of cold-induced thermogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; heart; integumental system; nervous system; and sensory organ. Orthologous to human IP6K1 (inositol hexakisphosphate kinase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 61.4), ovary adult (RPKM 49.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 59.07 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (107879847..107925981)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108002648..108048782)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
Title: The Ip6k1 and Ip6k2 Kinases Are Critical for Normal Renal Tubular Function.
Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
Title: Inositol hexakisphosphate kinase 1 is essential for cell junction integrity in the mouse seminiferous epithelium.
Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
Title: Pleiotropic actions of IP6K1 mediate hepatic metabolic dysfunction to promote nonalcoholic fatty liver disease and steatohepatitis.
Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
Title: Whole Body Ip6k1 Deletion Protects Mice from Age-Induced Weight Gain, Insulin Resistance and Metabolic Dysfunction.
Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
Title: Inositol pyrophosphates promote MYC polyubiquitination by FBW7 to regulate cell survival.
Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
Title: Inositol hexakisphosphate kinase-1 is a key mediator of prepulse inhibition and short-term fear memory.
the unique metabolic sensing properties of IP6K1 guarantees appropriate concentrations of IP7 and thereby both correct basal insulin secretion and intact first phase insulin release.
Title: Inositol hexakisphosphate kinase 1 is a metabolic sensor in pancreatic β-cells.
juvenile spermatids from Ip6k1(-/-) mice display premature expression of the transition protein TNP2 and the protamine PRM2 due to translational derepression.
Title: IP6K1 is essential for chromatoid body formation and temporal regulation of Tnp2 and Prm2 expression in mouse spermatids.
these findings reveal an important role for IP6K1 in regulating Mesenchymal stem/stromal cell fitness and differentiation fate.
Title: IP6K1 Reduces Mesenchymal Stem/Stromal Cell Fitness and Potentiates High Fat Diet-Induced Skeletal Involution.
IP6K1 physiologically regulates neuronal migration by binding to alpha-actinin and influencing phosphorylation of both FAK and alpha-actinin through its product 5-diphosphoinositol pentakisphosphate.
Title: Neuronal migration is mediated by inositol hexakisphosphate kinase 1 via α-actinin and focal adhesion kinase.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D9Dcr104 (e-PCR), detects polymorphism
- UniSTS:499006

AU022776 (e-PCR)
- UniSTS:208451

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 1-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 3-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol hexakisphosphate kinase activity	ISO Inferred from Sequence Orthology more info
enables inositol-1,3,4,5,6-pentakisphosphate kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within inositol metabolic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info	PubMed
involved_in negative regulation of cold-induced thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in fibrillar center	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inositol hexakisphosphate kinase 1

Names: inositol hexakisphosphate kinase 6; insP6 kinase 1

NP_038813.2

EC 2.7.4.21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013785.2 → NP_038813.2 inositol hexakisphosphate kinase 1

See identical proteins and their annotated locations for NP_038813.2

Status: PROVISIONAL

Source sequence(s)

BC059006

Consensus CDS

CCDS23514.1

UniProtKB/Swiss-Prot

Q6PD10, Q9QXV6

UniProtKB/TrEMBL

Q6A097

Related

ENSMUSP00000035214.5, ENSMUST00000035214.11

Conserved Domains (1) summary

pfam03770
Location:207 → 426

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

107879847..107925981

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_026266.1: Suppressed sequence

Description

NM_026266.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.