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    Spef1l sperm flagellar 1 like [ Mus musculus (house mouse) ]

    Gene ID: 381933, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Spef1lprovided by MGI
    Official Full Name
    sperm flagellar 1 likeprovided by MGI
    Primary source
    MGI:MGI:2685939
    See related
    Ensembl:ENSMUSG00000073795 AllianceGenome:MGI:2685939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1093; 6430531B16Rik
    Summary
    Predicted to enable actin binding activity and microtubule binding activity. Predicted to be involved in negative regulation of cell death; plasma membrane bounded cell projection assembly; and regulation of cytoskeleton organization. Predicted to be located in several cellular components, including basolateral plasma membrane; lamellipodium; and microvillus. Predicted to be active in axoneme. Orthologous to human SPEF1 (sperm flagellar 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 41.4), ovary adult (RPKM 2.7) and 1 other tissue See more
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    Genomic context

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    See Spef1l in Genome Data Viewer
    Location:
    7 F4; 7 84.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (139552211..139558668, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (139972298..139978755, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene 16201 Neighboring gene microRNA 7686 Neighboring gene microRNA 202 Neighboring gene STARR-positive B cell enhancer ABC_E10482 Neighboring gene STARR-positive B cell enhancer ABC_E11374 Neighboring gene a disintegrin and metallopeptidase domain 8 Neighboring gene microRNA 7062 Neighboring gene STARR-seq mESC enhancer starr_20441 Neighboring gene tubulin, gamma complex component 2 Neighboring gene STARR-seq mESC enhancer starr_20442 Neighboring gene STARR-positive B cell enhancer ABC_E6615 Neighboring gene STARR-positive B cell enhancer ABC_E8219 Neighboring gene zinc finger protein 511

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein LOC381933

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033465.3 → NP_001028637.1  uncharacterized protein LOC381933 isoform 1

      See identical proteins and their annotated locations for NP_001028637.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AK131789, BF152936
      Consensus CDS
      CCDS40172.1
      UniProtKB/TrEMBL
      Q3V2J1
      Related
      ENSMUSP00000095584.3, ENSMUST00000097970.9
      Conserved Domains (1) summary
      pfam06294
      Location:23 → 113
      CH_2; CH-like domain in sperm protein

    2. NM_001347613.2 → NP_001334542.1  uncharacterized protein LOC381933 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice junction and lacks an alternate coding exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC107822
      Consensus CDS
      CCDS85450.1
      UniProtKB/TrEMBL
      A0A1B0GR09, Q3TNW9
      Related
      ENSMUSP00000147330.2, ENSMUST00000210254.2

    3. NM_001347614.2 → NP_001334543.1  uncharacterized protein LOC381933 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC107822
      Consensus CDS
      CCDS85449.1
      UniProtKB/TrEMBL
      A0A1B0GT96, Q3TNW9
      Related
      ENSMUSP00000148257.2, ENSMUST00000209335.2

    4. NM_001359836.1 → NP_001346765.1  uncharacterized protein LOC381933 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC107822
      UniProtKB/TrEMBL
      Q3TNW9
      Conserved Domains (1) summary
      pfam06294
      Location:22 → 113
      CH_2; CH-like domain in sperm protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      139552211..139558668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153205.1 → XP_036009098.1  uncharacterized protein LOC381933 isoform X2

    2. XM_036153204.1 → XP_036009097.1  uncharacterized protein LOC381933 isoform X1

      UniProtKB/TrEMBL
      Q3TNW9
      Related
      ENSMUSP00000113338.2, ENSMUST00000121412.2
      Conserved Domains (1) summary
      pfam06294
      Location:22 → 113
      CH_2; CH-like domain in sperm protein
    Nucleotide Protein Strain
    Heading Accession and Version

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