Draxin dorsal inhibitory axon guidance protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Draxinprovided by MGI
Official Full Name: dorsal inhibitory axon guidance proteinprovided by MGI
Primary source: MGI:MGI:1917683
See related: Ensembl:ENSMUSG00000029005 AllianceGenome:MGI:1917683
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: neucrin; 2610109H07Rik
Summary: Involved in negative regulation of canonical Wnt signaling pathway; negative regulation of neuron projection development; and nervous system development. Acts upstream of or within negative regulation of axon extension and negative regulation of neuron apoptotic process. Located in extracellular region. Is expressed in several structures, including central nervous system; dorsal root ganglion; future brain; neural retina; and vibrissa. Orthologous to human DRAXIN (dorsal inhibitory axon guidance protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in whole brain E14.5 (RPKM 14.9), CNS E14 (RPKM 13.3) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 E1- E2; 4 78.67 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (148182894..148215582, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (148098437..148131139, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.
Title: DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation.
draxin regulates the proapoptotic activity of DCC in the subgranular zone by directly interacting with the DCC dependence receptor and not by preventing the interaction between prosurvival Netrin-1 and DCC.
Title: Draxin regulates hippocampal neurogenesis in the postnatal dentate gyrus by inhibiting DCC-induced apoptosis.
draxin is a key molecule in the regulation of mossy fiber projections.
Title: The chemorepellent draxin is involved in hippocampal mossy fiber projection.
draxin may regulate mouse trunk neural crest cell migration.
Title: A potential inhibitory function of draxin in regulating mouse trunk neural crest migration.
These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors.
Title: Draxin from neocortical neurons controls the guidance of thalamocortical projections into the neocortex.
Study elucidates for the first time, molecular events in draxin repulsion and links draxin and DCC to MAP1B to axon guidance cue signaling.
Title: Repulsive axon guidance by Draxin is mediated by protein Kinase B (Akt), glycogen synthase kinase-3β (GSK-3β) and microtubule-associated protein 1B.
The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation
Title: The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation.
Draxin interacts with subnanomolar affinity to the netrin receptor DCC, in a region of DCC distinct from its netrin-binding domain.
Title: Draxin inhibits axonal outgrowth through the netrin receptor DCC.
These results suggest that draxin functions as an inhibitory guidance cue for olfactory bulb axons and indicate its contribution to the formation of the lateral olfactory tract.
Title: Olfactory bulb axonal outgrowth is inhibited by draxin.
This study found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus.
Title: Draxin, a repulsive axon guidance protein, is involved in hippocampal development.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125553 (e-PCR)
- UniSTS:162367

NoName (e-PCR)
- UniSTS:235095

RH125727 (e-PCR)
- UniSTS:142493

2610109H07Rik (e-PCR), detects polymorphism
- UniSTS:528038

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in anterior commissure morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in commissural neuron differentiation in spinal cord	IBA Inferred from Biological aspect of Ancestor more info
involved_in commissural neuron differentiation in spinal cord	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dorsal spinal cord development	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in forebrain development	IBA Inferred from Biological aspect of Ancestor more info
involved_in forebrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of axon extension	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: draxin

Names: dorsal repulsive axon guidance protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.