Cmtm2a CKLF-like MARVEL transmembrane domain containing 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cmtm2aprovided by MGI
Official Full Name: CKLF-like MARVEL transmembrane domain containing 2Aprovided by MGI
Primary source: MGI:MGI:2447160
See related: Ensembl:ENSMUSG00000074127 AllianceGenome:MGI:2447160
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: C32; Cklf; ARR19; CKLF3; CKLF4; CKLF5; Cklf1; UCK-1; Cklfsf2a; Cklfsf2-1b; 1700001K04Rik; 1700041N15Rik; 1700063K20Rik
Summary: Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription, DNA-templated and regulation of testosterone biosynthetic process. Located in cytoplasm and nucleus. Orthologous to human CMTM2 (CKLF like MARVEL transmembrane domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward testis adult (RPKM 417.5) See more
Orthologs: human all
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Genomic context

Location:: 8 D3; 8 53.04 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (105007674..105019813, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (104281042..104293181, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke.
Title: A breakdown of metabolic reprogramming in microglia induced by CKLF1 exacerbates immune tolerance in ischemic stroke.
CKLF1 is an important mediator that skewing microglia/macrophage toward M1 phenotype at early stage of cerebral ischemic injury
Title: CKLF1 Aggravates Focal Cerebral Ischemia Injury at Early Stage Partly by Modulating Microglia/Macrophage Toward M1 Polarization Through CCR4.
co-expression of sperm membrane proteins CMTM2A and CMTM2B is required for male fertility and affects the localization of the sperm membrane protein ADAM3 in regulating sperm fertilizing ability.
Title: Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.
Taken together, these results suggest that ARR19 may play an important role in the differentiation of male reproductive organs such as testis and prostate
Title: A time-course study of long term over-expression of ARR19 in mice.
Concluding, the temporal expression pattern of CKLF1 was coincident with the postnatal developmental stages and the spatial locations of CKLF1 were some destinations of neural cell migration or regions where myelination normally occurs.
Title: Developmental expression of chemokine-like factor 1, a novel member of chemokines family, in postnatal rat cerebral cortex.
ARR19 acts as a novel coregulator of Nur77, in turn regulating Nur77-induced testicular steroidogenesis.
Title: Anti-steroidogenic factor ARR19 inhibits testicular steroidogenesis through the suppression of Nur77 transactivation.
ARR19 gene expression in testicular Leydig cells is regulated by luteinizing hormone/cAMP signaling via the control of GATA-1 expression, resulting in the control of testicular steroidogenesis
Title: ARR19 (androgen receptor corepressor of 19 kDa), an antisteroidogenic factor, is regulated by GATA-1 in testicular Leydig cells.
Overexpression of chemokine-like factor 2 promotes the proliferation and survival of C2C12 skeletal muscle cells.
Title: Overexpression of chemokine-like factor 2 promotes the proliferation and survival of C2C12 skeletal muscle cells.
ARR19 may act as an androgen receptor corepressor in vivo and play an important role in male reproductive functions
Title: Androgen receptor corepressor-19 kDa (ARR19), a leucine-rich protein that represses the transcriptional activity of androgen receptor through recruitment of histone deacetylase.
Data show that mouse Cklfsf2a and Cklfsf2b are two homologues of human CKLFSF2.
Title: Molecular cloning and identification of mouse Cklfsf2a and Cklfsf2b, two homologues of human CKLFSF2.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of testosterone biosynthetic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: CKLF-like MARVEL transmembrane domain-containing protein 2A

Names: chemokine-like factor super family 2A; chemokine-like factor superfamily 2-1b; chemokine-like factor superfamily member 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.