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    Hnmt histamine N-methyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 140483, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Hnmtprovided by MGI
    Official Full Name
    histamine N-methyltransferaseprovided by MGI
    Primary source
    MGI:MGI:2153181
    See related
    Ensembl:ENSMUSG00000026986 AllianceGenome:MGI:2153181
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500031F01Rik
    Summary
    Enables N-methyltransferase activity. Predicted to be involved in histamine catabolic process and methylation. Predicted to act upstream of or within regulation of neurotransmitter levels. Predicted to be located in several cellular components, including centrosome; neuron projection; and nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Parkinson's disease; asthma; atopic dermatitis; autosomal recessive non-syndromic intellectual disability; and essential tremor. Orthologous to human HNMT (histamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in frontal lobe adult (RPKM 4.2), cortex adult (RPKM 3.6) and 14 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hnmt in Genome Data Viewer
    Location:
    2 A3; 2 16.06 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (23892923..23939756, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (24002911..24049758, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2D 3 pseudogene Neighboring gene speckle-type BTB/POZ protein-like Neighboring gene STARR-positive B cell enhancer mm9_chr2:23427670-23427971 Neighboring gene STARR-seq mESC enhancer starr_03932 Neighboring gene SH3 domain protein 2C, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_03933 Neighboring gene STARR-seq mESC enhancer starr_03934 Neighboring gene STARR-seq mESC enhancer starr_03935 Neighboring gene STARR-seq mESC enhancer starr_03936 Neighboring gene STARR-seq mESC enhancer starr_03937 Neighboring gene STARR-seq mESC enhancer starr_03939 Neighboring gene STARR-seq mESC enhancer starr_03940 Neighboring gene STARR-seq mESC enhancer starr_03942 Neighboring gene STARR-seq mESC enhancer starr_03943 Neighboring gene STARR-seq mESC enhancer starr_03944 Neighboring gene TATA box binding protein like 2 Neighboring gene STARR-seq mESC enhancer starr_03945 Neighboring gene STARR-seq mESC enhancer starr_03946 Neighboring gene interleukin 36B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Contribution of astrocytic histamine N-methyltransferase to histamine clearance and brain function in mice. Otsuka R, et al. Neuropharmacology, 2022 Jul 1. PMID 35487272
    2. Histamine N-methyltransferase regulates aggression and the sleep-wake cycle. Naganuma F, et al. Sci Rep, 2017 Nov 21. PMID 29162912, Free PMC Article
    3. Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice. Furukawa F, et al. Autoimmun Rev, 2009 May. PMID 19162242
    4. Genomic structure of the rat and mouse histamine N-methyltransferase gene. Kitanaka N, et al. Jpn J Pharmacol, 2002 Jan. PMID 11855681
    5. Human histamine N-methyltransferase pharmacogenetics: common genetic polymorphisms that alter activity. Preuss CV, et al. Mol Pharmacol, 1998 Apr. PMID 9547362

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
      Title: Sexually Dimorphic Effects of Histamine Degradation by Enteric Glial Histamine N-Methyltransferase (HNMT) on Visceral Hypersensitivity.
    2. KO mice exhibited high aggressive behaviours and exhibited prolonged bouts of awakening during the light (inactive) period and compensatory sleep during the dark (active) period.
      Title: Histamine N-methyltransferase regulates aggression and the sleep-wake cycle.
    3. decreasing expression over the time course of the skin pathological changes in MRL/lpr mice
      Title: Mast cells and histamine metabolism in skin lesions from MRL/MP-lpr/lpr mice.
    4. Genomic structure of the rat and mouse histamine N-methyltransferase gene
      Title: Genomic structure of the rat and mouse histamine N-methyltransferase gene.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables N-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histamine N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in histamine metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    histamine N-methyltransferase
    Names
    HMT
    NP_536710.1
    XP_006497733.1
    XP_006497734.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080462.2 → NP_536710.1  histamine N-methyltransferase

      See identical proteins and their annotated locations for NP_536710.1

      Status: VALIDATED

      Source sequence(s)
      AF297037, AK160131, AW456742
      Consensus CDS
      CCDS15731.1
      UniProtKB/Swiss-Prot
      Q3TVH0, Q91VF2
      UniProtKB/TrEMBL
      A2AQK4
      Related
      ENSMUSP00000062747.6, ENSMUST00000051416.12
      Conserved Domains (1) summary
      pfam13489
      Location:32 → 218
      Methyltransf_23; Methyltransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      23892923..23939756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497670.4 → XP_006497733.1  histamine N-methyltransferase isoform X1

      Conserved Domains (1) summary
      pfam13489
      Location:44 → 230
      Methyltransf_23; Methyltransferase domain

    2. XM_006497671.5 → XP_006497734.1  histamine N-methyltransferase isoform X2

      See identical proteins and their annotated locations for XP_006497734.1

      UniProtKB/Swiss-Prot
      Q3TVH0, Q91VF2
      UniProtKB/TrEMBL
      A2AQK4
      Related
      ENSMUSP00000110142.2, ENSMUST00000114498.8
      Conserved Domains (1) summary
      pfam13489
      Location:32 → 218
      Methyltransf_23; Methyltransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91VF2.1 GenPept UniProtKB/Swiss-Prot:Q91VF2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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