Kiss1 KiSS-1 metastasis-suppressor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Kiss1provided by MGI
Official Full Name: KiSS-1 metastasis-suppressorprovided by MGI
Primary source: MGI:MGI:2663985
See related: Ensembl:ENSMUSG00000115958 Ensembl:ENSMUSG00000116158 AllianceGenome:MGI:2663985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: kisspeptin; metastatin
Summary: Predicted to enable kisspeptin receptor binding activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; decidualization; and negative regulation of cell migration. Predicted to be located in several cellular components, including apical plasma membrane; extracellular space; and neuronal cell body. Predicted to be active in neuron projection. Is expressed in diencephalon and metanephros. Used to study hypogonadotropic hypogonadism 13 with or without anosmia. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 13 with or without anosmia. Orthologous to human KISS1 (KiSS-1 metastasis suppressor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 7.1), genital fat pad adult (RPKM 4.0) and 12 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 57.91 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (133249625..133257460)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (133321887..133329722)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
Title: STAT4 targets KISS1 to inhibit the oxidative damage, inflammation and neuronal apoptosis in experimental PD models by inactivating the MAPK pathway.
Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
Title: Deletion of Androgen Receptors From Kisspeptin Neurons Prevents PCOS Features in a Letrozole Mouse Model.
Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.
Title: Kisspeptin regulates airway hyperresponsiveness and remodeling in a mouse model of asthma.
Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
Title: Kisspeptin induces Kiss-1 and GnRH gene expression in mHypoA-55 hypothalamic cell models: Involvement of the ERK and PKA signaling pathways.
SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Title: SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice.
Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Title: Deletion of GABAB receptors from Kiss1 cells affects glucose homeostasis without altering reproduction in male mice.
Optogenetic stimulation of Kiss1[ARC] terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice.
Title: Optogenetic stimulation of Kiss1(ARC) terminals in the AVPV induces surge-like luteinizing hormone secretion via glutamate release in mice.
Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.
Title: Socs3 ablation in kisspeptin cells partially prevents lipopolysaccharide-induced body weight loss.
Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice.
Title: Prenatal androgen treatment impairs the suprachiasmatic nucleus arginine-vasopressin to kisspeptin neuron circuit in female mice.
Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.
Title: Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice.

Submit: New GeneRIF Correction See all GeneRIFs (139)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491906

Kiss1 (e-PCR), detects polymorphism
- UniSTS:547515

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables kisspeptin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables kisspeptin receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in generation of ovulation cycle rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cell migration	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of luteinizing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: metastasis-suppressor KiSS-1

Names: 0610012C01Rik; Kiss1 metastasis-suppressor; kisspeptin-1; metastin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001412624.1 → NP_001399553.1 metastasis-suppressor KiSS-1 precursor

Status: VALIDATED

Source sequence(s)

AC068906

UniProtKB/Swiss-Prot

Q149Z8, Q68Y93, Q6Y4S4, Q80XF6

UniProtKB/TrEMBL

I0J0X7

Related

ENSMUSP00000136746.2, ENSMUST00000178033.5
NM_178260.4 → NP_839991.2 metastasis-suppressor KiSS-1 precursor

See identical proteins and their annotated locations for NP_839991.2

Status: VALIDATED

Source sequence(s)

AC068906

Consensus CDS

CCDS48362.1

UniProtKB/Swiss-Prot

Q149Z8, Q68Y93, Q6Y4S4, Q80XF6

UniProtKB/TrEMBL

I0J0X7

Related

ENSMUSP00000142264.2, ENSMUST00000195286.5

Conserved Domains (1) summary

pfam15152
Location:42 → 116

Kisspeptin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

133249625..133257460

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529682.2 → XP_006529745.1 metastasis-suppressor KiSS-1 isoform X4

UniProtKB/Swiss-Prot

Q149Z8, Q68Y93, Q6Y4S4, Q80XF6

Conserved Domains (1) summary

pfam15152
Location:68 → 142

Kisspeptin
XM_006529681.1 → XP_006529744.1 metastasis-suppressor KiSS-1 isoform X3

Conserved Domains (1) summary

pfam15152
Location:93 → 167

Kisspeptin
XM_030254793.1 → XP_030110653.1 metastasis-suppressor KiSS-1 isoform X5

UniProtKB/Swiss-Prot

Q149Z8, Q68Y93, Q6Y4S4, Q80XF6

UniProtKB/TrEMBL

I0J0X7

Conserved Domains (1) summary

pfam15152
Location:42 → 116

Kisspeptin