Rhox2a reproductive homeobox 2A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rhox2aprovided by MGI
Official Full Name: reproductive homeobox 2Aprovided by MGI
Primary source: MGI:MGI:1922449
See related: Ensembl:ENSMUSG00000051827 AllianceGenome:MGI:1922449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rhox2; Rhox2.1; 4930539I12Rik
Summary: Predicted to enable identical protein binding activity and sequence-specific double-stranded DNA binding activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Orthologous to human RHOXF2 (Rhox homeobox family member 2) and RHOXF2B (Rhox homeobox family member 2B). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: This gene was previously named "Rhox2" by MacLean, et. al. Genesis (2006) 44:122 (PubMed ID: 16496311) and "Rhox2.1" by Morris, et. al. Mamm. Genome (2006) 17:178 (PubMed ID: 16465597). Its official nomenclature is now Rhox2a. [07 Jan 2013]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: X A3.3; X 21.67 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (36508645..36513343)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (37244992..37249690)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: reproductive homeobox 2A

Names: reproductive homeobox on X chromosome, 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310503.1 → NP_001297432.1 reproductive homeobox 2A isoform 2

See identical proteins and their annotated locations for NP_001297432.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon, which results in a frameshift, compared to variant 1. The resulting protein (isoform 2) has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK015997, AL451076, BX637526

Consensus CDS

CCDS81118.1

UniProtKB/TrEMBL

G3UYY0, V9GXL3

Related

ENSMUSP00000134267.2, ENSMUST00000173650.2

Conserved Domains (1) summary

cd00086
Location:134 → 181

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
NM_029203.2 → NP_083479.1 reproductive homeobox 2A isoform 1

See identical proteins and their annotated locations for NP_083479.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer protein (isoform 1).

Source sequence(s)

AK015997, BX637526

Consensus CDS

CCDS30075.1

UniProtKB/TrEMBL

Q9D4Y3, V9GXL3

Related

ENSMUSP00000067190.6, ENSMUST00000063340.12

Conserved Domains (1) summary

cd00086
Location:134 → 186

homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.