Acaa1b acetyl-Coenzyme A acyltransferase 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acaa1bprovided by MGI
Official Full Name: acetyl-Coenzyme A acyltransferase 1Bprovided by MGI
Primary source: MGI:MGI:3605455
See related: Ensembl:ENSMUSG00000010651 AllianceGenome:MGI:3605455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable C-acyltransferase activity; acetate CoA-transferase activity; and palmitoyl-CoA oxidase activity. Predicted to be involved in monocarboxylic acid metabolic process. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in alimentary system; chondrocranium; ganglia; genitourinary system; and metencephalon basal plate. Orthologous to human ACAA1 (acetyl-CoA acyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 383.0), kidney adult (RPKM 114.5) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F3; 9 71.33 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (118977111..118986149, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (119148043..119157093, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

acetyl-Coenzyme A acyltransferase 1B is involved in the regulation of genes encoding cholesterol biosynthesis enzymes in the liver
Title: A role for the peroxisomal 3-ketoacyl-CoA thiolase B enzyme in the control of PPARα-mediated upregulation of SREBP-2 target genes in the liver.
Molecular cloning, gene structure and tissue distribution of 3-ketoacyl-CoA thiolase B.
Title: Molecular cloning, gene structure and expression profile of two mouse peroxisomal 3-ketoacyl-CoA thiolase genes.
The region of the peroxisomal 3-ketoacyl-CoA thiolase B gene encoding the catalytic site was disrupted by homologous recombination in order to analyze the phenotype of these thiolase B-deficient mice.
Title: Targeted disruption of the peroxisomal thiolase B gene in mouse: a new model to study disorders related to peroxisomal lipid metabolism.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

Acaa1b (e-PCR), detects polymorphism
- UniSTS:546620

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetate CoA-transferase activity	ISO Inferred from Sequence Orthology more info
enables acetyl-CoA C-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA C-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA C-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables palmitoyl-CoA oxidase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in bile acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid beta-oxidation	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid beta-oxidation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in phenylacetate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in very long-chain fatty acid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in mitochondrion	HDA more info	PubMed
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
is_active_in peroxisome	ISO Inferred from Sequence Orthology more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: 3-ketoacyl-CoA thiolase B, peroxisomal

Names: acetyl-CoA acyltransferase B; beta-ketothiolase B; peroxisomal 3-oxoacyl-CoA thiolase B

NP_001397554.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

NP_666342.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_006512179.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

XP_011241272.1

EC 2.3.1.155

EC 2.3.1.16

EC 2.3.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001410625.1 → NP_001397554.1 3-ketoacyl-CoA thiolase B, peroxisomal isoform 2

Status: VALIDATED

Source sequence(s)

AC055818
NM_146230.4 → NP_666342.1 3-ketoacyl-CoA thiolase B, peroxisomal isoform 1 precursor

Status: VALIDATED

Source sequence(s)

AC055818

Consensus CDS

CCDS23608.1

UniProtKB/Swiss-Prot

Q8VCH0

UniProtKB/TrEMBL

Q3TUU3, Q3UKM0

Related

ENSMUSP00000010795.5, ENSMUST00000010795.5

Conserved Domains (2) summary

PLN02287
Location:1 → 420

PLN02287; 3-ketoacyl-CoA thiolase

cd00751
Location:39 → 421

thiolase; Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

118977111..118986149 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011242970.1 → XP_011241272.1 3-ketoacyl-CoA thiolase B, peroxisomal isoform X1

UniProtKB/TrEMBL

Q3TUU3

Conserved Domains (1) summary

PLN02287
Location:23 → 356

PLN02287; 3-ketoacyl-CoA thiolase
XM_006512116.5 → XP_006512179.1 3-ketoacyl-CoA thiolase B, peroxisomal isoform X3

UniProtKB/TrEMBL

H3BKA1

Conserved Domains (1) summary

PLN02287
Location:1 → 209

PLN02287; 3-ketoacyl-CoA thiolase