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    Unk unkempt family zinc finger [ Mus musculus (house mouse) ]

    Gene ID: 217331, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Unkprovided by MGI
    Official Full Name
    unkempt family zinc fingerprovided by MGI
    Primary source
    MGI:MGI:2442456
    See related
    Ensembl:ENSMUSG00000020770 AllianceGenome:MGI:2442456
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Unkh; Zc3h5; Zc3hdc5; mKIAA1753; B230379M23Rik
    Summary
    Enables mRNA CDS binding activity and polysome binding activity. Acts upstream of or within cell morphogenesis involved in neuron differentiation; in utero embryonic development; and neuron migration. Predicted to be located in cytoplasm. Predicted to be part of polysome. Is expressed in central nervous system; early conceptus; future brain; oocyte; and retina nuclear layer. Orthologous to human UNK (unk zinc finger). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 15.6), limb E14.5 (RPKM 14.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Unk in Genome Data Viewer
    Location:
    11 E2; 11 80.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (115921117..115952040)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (116028616..116061214)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene integrin beta 4 Neighboring gene RIKEN cDNA B230344G16 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115873522-115873709 Neighboring gene galactokinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E306 Neighboring gene STARR-seq mESC enhancer starr_31191 Neighboring gene H3.3 histone B Neighboring gene STARR-seq mESC enhancer starr_31192 Neighboring gene predicted gene, 38482 Neighboring gene unc-13 homolog D Neighboring gene STARR-positive B cell enhancer ABC_E10732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:115939592-115939779 Neighboring gene STARR-positive B cell enhancer ABC_E381 Neighboring gene WW domain binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt. Murn J, et al. Nat Struct Mol Biol, 2016 Jan. PMID 26641712, Free PMC Article
    2. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis. Baskaran P, et al. J Biol Chem, 2023 Jan. PMID 36509146, Free PMC Article
    3. The embryonically active gene, unkempt, of Drosophila encodes a Cys3His finger protein. Mohler J, et al. Genetics, 1992 Jun. PMID 1339381, Free PMC Article
    4. Hectd1 is required for development of the junctional zone of the placenta. Sarkar AA, et al. Dev Biol, 2014 Aug 15. PMID 24855001, Free PMC Article
    5. The zinc finger/RING domain protein Unkempt regulates cognitive flexibility. Vinsland E, et al. Sci Rep, 2021 Aug 11. PMID 34381067, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.
      Title: Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.
    2. The authors determined the X-ray crystal structure of mouse Unkempt and show that its six CCCH zinc fingers (ZnFs) form two compact clusters, ZnF1-3 and ZnF4-6, that recognize distinct trinucleotide RNA substrates.
      Title: Recognition of distinct RNA motifs by the clustered CCCH zinc fingers of neuronal protein Unkempt.
    3. Depletion of Unkempt in mouse embryos disrupts the shape of migrating neurons, while ectopic expression confers neuronal-like morphology to cells of different nonneuronal lineages.
      Title: Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA CDS binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA CDS binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA CDS binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell morphogenesis involved in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis involved in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of cytoplasmic translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RING finger protein unkempt homolog
    Names
    unkempt homolog
    zinc finger CCCH domain-containing protein 5
    zinc finger CCCH type containing 5
    zinc finger CCCH type domain containing 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286006.1 → NP_001272935.1  RING finger protein unkempt homolog isoform 2

      See identical proteins and their annotated locations for NP_001272935.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AK134361, BB619163, BC033048
      Consensus CDS
      CCDS70351.1
      UniProtKB/TrEMBL
      Q3UYU7
      Related
      ENSMUSP00000102060.2, ENSMUST00000106452.2
      Conserved Domains (3) summary
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:633 → 706
      DegS; Sensor protein DegS
      pfam13920
      Location:752 → 788
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    2. NM_172569.4 → NP_766157.1  RING finger protein unkempt homolog isoform 1

      See identical proteins and their annotated locations for NP_766157.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK046395, BB619163, BC033048
      Consensus CDS
      CCDS25655.1
      UniProtKB/Swiss-Prot
      A2A853, Q8BL48, Q8BVI6, Q99JZ8, Q99LL9
      Related
      ENSMUSP00000021116.6, ENSMUST00000021116.12
      Conserved Domains (3) summary
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam05384
      Location:646 → 719
      DegS; Sensor protein DegS
      pfam13920
      Location:765 → 801
      zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      115921117..115952040
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533088.5 → XP_006533151.1  RING finger protein unkempt homolog isoform X1

      Conserved Domains (6) summary
      PHA03307
      Location:300 → 571
      PHA03307; transcriptional regulator ICP4; Provisional
      COG4372
      Location:625 → 730
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02680
      Location:485 → 733
      TIGR02680; TIGR02680 family protein
      cd16614
      Location:740 → 773
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:294 → 318
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18384
      Location:34 → 69
      zf_CCCH_5; Unkempt Zinc finger domain 1 (Znf1)

    2. XM_030245897.2 → XP_030101757.1  RING finger protein unkempt homolog isoform X3

      Conserved Domains (5) summary
      smart00356
      Location:47 → 71
      ZnF_C3H1; zinc finger
      COG4372
      Location:457 → 562
      COG4372; Uncharacterized conserved protein, contains DUF3084 domain [Function unknown]
      TIGR02680
      Location:317 → 565
      TIGR02680; TIGR02680 family protein
      cd16614
      Location:572 → 605
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126 → 150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    3. XM_006533089.4 → XP_006533152.1  RING finger protein unkempt homolog isoform X2

      Related
      ENSMUST00000150759.8
      Conserved Domains (4) summary
      smart00356
      Location:47 → 71
      ZnF_C3H1; zinc finger
      PRK11448
      Location:452 → 583
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:600 → 633
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126 → 150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    4. XM_036156606.1 → XP_036012499.1  RING finger protein unkempt homolog isoform X5

      Conserved Domains (2) summary
      PRK11448
      Location:306 → 437
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:454 → 487
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins

    5. XM_036156605.1 → XP_036012498.1  RING finger protein unkempt homolog isoform X4

      UniProtKB/TrEMBL
      Q3V2Z5
      Conserved Domains (2) summary
      PRK11448
      Location:319 → 450
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:467 → 500
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins

    6. XM_017314490.3 → XP_017169979.1  RING finger protein unkempt homolog isoform X2

      Conserved Domains (4) summary
      smart00356
      Location:47 → 71
      ZnF_C3H1; zinc finger
      PRK11448
      Location:452 → 583
      hsdR; type I restriction enzyme EcoKI subunit R; Provisional
      cd16614
      Location:600 → 633
      RING-HC_UNK_like; RING finger, HC subclass, found in RING finger protein unkempt (UNK), unkempt-like (UNKL), and similar proteins
      pfam00642
      Location:126 → 150
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)

    RNA

    1. XR_001779962.3 RNA Sequence

    2. XR_001779963.3 RNA Sequence

    3. XR_001779964.3 RNA Sequence

    4. XR_003949402.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BL48.1 GenPept UniProtKB/Swiss-Prot:Q8BL48

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