Brpf3 bromodomain and PHD finger containing, 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Brpf3provided by MGI
Official Full Name: bromodomain and PHD finger containing, 3provided by MGI
Primary source: MGI:MGI:2146836
See related: Ensembl:ENSMUSG00000063952 AllianceGenome:MGI:2146836
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1286
Summary: Predicted to enable histone binding activity. Predicted to be involved in histone H3-K14 acetylation and positive regulation of DNA replication. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be part of MOZ/MORF histone acetyltransferase complex. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; sensory organ; and skeleton. Orthologous to human BRPF3 (bromodomain and PHD finger containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E14.5 (RPKM 22.7), liver E14 (RPKM 19.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 A3.3; 17 15.03 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (29020088..29057763)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (28801126..28838789)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results indicate that BRPF3 forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
Title: The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to histone H3K14 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K12 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K5 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
contributes_to histone H4K8 acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of developmental process	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of hemopoiesis	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of MOZ/MORF histone acetyltransferase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of MOZ/MORF histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
part_of histone acetyltransferase complex	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bromodomain and PHD finger-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081315.1 → NP_001074784.1 bromodomain and PHD finger-containing protein 3

See identical proteins and their annotated locations for NP_001074784.1

Status: PROVISIONAL

Source sequence(s)

AC140278

Consensus CDS

CCDS37532.1

UniProtKB/Swiss-Prot

A0A3B2WAQ0, B2KF05, Q3TRM7

Related

ENSMUSP00000004985.10, ENSMUST00000004985.11

Conserved Domains (4) summary

cd05839
Location:1073 → 1188

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J

Range

29020088..29057763

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006524328.5 → XP_006524391.1 bromodomain and PHD finger-containing protein 3 isoform X2

See identical proteins and their annotated locations for XP_006524391.1

Related

ENSMUSP00000156455.2, ENSMUST00000233701.2

Conserved Domains (4) summary

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

PHA03307
Location:828 → 1095

PHA03307; transcriptional regulator ICP4; Provisional

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_036160628.1 → XP_036016521.1 bromodomain and PHD finger-containing protein 3 isoform X3

Conserved Domains (4) summary

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

PHA03307
Location:831 → 1037

PHA03307; transcriptional regulator ICP4; Provisional

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_006524330.5 → XP_006524393.1 bromodomain and PHD finger-containing protein 3 isoform X4

See identical proteins and their annotated locations for XP_006524393.1

Conserved Domains (3) summary

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_006524331.4 → XP_006524394.1 bromodomain and PHD finger-containing protein 3 isoform X5

See identical proteins and their annotated locations for XP_006524394.1

UniProtKB/TrEMBL

A0A3B2WCX7

Conserved Domains (3) summary

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_006524334.4 → XP_006524397.1 bromodomain and PHD finger-containing protein 3 isoform X7

See identical proteins and their annotated locations for XP_006524397.1

UniProtKB/TrEMBL

A0A3B2WD38

Related

ENSMUSP00000156836.2, ENSMUST00000232705.2

Conserved Domains (2) summary

COG5141
Location:117 → 622

COG5141; PHD zinc finger-containing protein [General function prediction only]

cl22851
Location:269 → 386

PHD_SF; PHD finger superfamily
XM_006524326.5 → XP_006524389.1 bromodomain and PHD finger-containing protein 3 isoform X1

See identical proteins and their annotated locations for XP_006524389.1

UniProtKB/Swiss-Prot

A0A3B2WAQ0, B2KF05, Q3TRM7

Conserved Domains (4) summary

cd05839
Location:1073 → 1188

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_030249830.2 → XP_030105690.1 bromodomain and PHD finger-containing protein 3 isoform X1

UniProtKB/Swiss-Prot

A0A3B2WAQ0, B2KF05, Q3TRM7

Conserved Domains (4) summary

cd05839
Location:1073 → 1188

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:592 → 689

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

COG5141
Location:117 → 603

COG5141; PHD zinc finger-containing protein [General function prediction only]

cd15703
Location:269 → 386

ePHD_BRPF3; Extended PHD finger found in bromodomain and PHD finger-containing protein 3 (BRPF3) and similar proteins
XM_006524332.5 → XP_006524395.1 bromodomain and PHD finger-containing protein 3 isoform X6

See identical proteins and their annotated locations for XP_006524395.1

UniProtKB/TrEMBL

Q6ZPU7

Related

ENSMUSP00000156780.2, ENSMUST00000156029.8

Conserved Domains (2) summary

cd05839
Location:575 → 690

BR140_related; The PWWP domain is found in the BR140 family, which includes peregrin and BR140-like proteins 1 and 2. BR140 is the only family to contain the PWWP domain at the C terminus, with PHD and bromo domains in the N-terminal region. In myeloid leukemias, ...

cd05512
Location:94 → 191

Bromo_brd1_like; Bromodomain; brd1_like subfamily. BRD1 is a mammalian gene which encodes for a nuclear protein assumed to be a transcriptional regulator. BRD1 has been implicated with brain development and susceptibility to schizophrenia and bipolar affective disorder. ...

RNA

XR_003952129.2 RNA Sequence
XR_004939534.1 RNA Sequence
XR_385332.5 RNA Sequence
XR_004939535.1 RNA Sequence
XR_003952130.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_199061.1: Suppressed sequence

Description

NM_199061.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.