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    Zdhhc19 zinc finger, DHHC domain containing 19 [ Mus musculus (house mouse) ]

    Gene ID: 245308, updated on 12-May-2024

    Summary

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    Official Symbol
    Zdhhc19provided by MGI
    Official Full Name
    zinc finger, DHHC domain containing 19provided by MGI
    Primary source
    MGI:MGI:2682948
    See related
    Ensembl:ENSMUSG00000052363 AllianceGenome:MGI:2682948
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm616; Gm1744
    Summary
    Predicted to enable protein-cysteine S-palmitoyltransferase activity. Predicted to be involved in peptidyl-L-cysteine S-palmitoylation and protein targeting to membrane. Predicted to be located in Golgi membrane and perinucleolar compartment. Predicted to be active in Golgi apparatus and endoplasmic reticulum. Orthologous to human ZDHHC19 (zinc finger DHHC-type palmitoyltransferase 19). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward testis adult (RPKM 76.6) See more
    Orthologs
    human all
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    Genomic context

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    See Zdhhc19 in Genome Data Viewer
    Location:
    16 B3; 16 22.76 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (32315059..32326032)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (32496241..32507214)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr16:32430841-32431142 Neighboring gene STARR-positive B cell enhancer ABC_E9428 Neighboring gene phosphate cytidylyltransferase 1, choline, alpha isoform Neighboring gene solute carrier family 51, alpha subunit Neighboring gene STARR-seq mESC enhancer starr_40658 Neighboring gene STARR-seq mESC enhancer starr_40663 Neighboring gene STARR-seq mESC enhancer starr_40664 Neighboring gene STARR-seq mESC enhancer starr_40665 Neighboring gene SET domain containing 6 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7444 Neighboring gene transferrin receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice. Wang S, et al. Int J Mol Sci, 2021 Aug 18. PMID 34445597, Free PMC Article
    2. ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†. Wu Y, et al. Biol Reprod, 2022 Mar 19. PMID 34897408
    3. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesisdagger.
      Title: ZDHHC19 localizes to the cell membrane of spermatids and is involved in spermatogenesis†.
    2. ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice.
      Title: ZDHHC19 Is Dispensable for Spermatogenesis, but Is Essential for Sperm Functions in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC58833

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-L-cysteine S-palmitoylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of aggrephagy ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinucleolar compartment ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC19
    Names
    DHHC-19
    probable palmitoyltransferase ZDHHC19
    zinc finger DHHC domain-containing protein 19
    NP_955013.1
    XP_006522198.1
    XP_011244202.1
    XP_030104974.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199309.2 → NP_955013.1  palmitoyltransferase ZDHHC19

      See identical proteins and their annotated locations for NP_955013.1

      Status: PROVISIONAL

      Source sequence(s)
      AC140186
      Consensus CDS
      CCDS28122.1
      UniProtKB/Swiss-Prot
      Q810M5
      UniProtKB/TrEMBL
      B9EIU6
      Related
      ENSMUSP00000070727.8, ENSMUST00000064192.8
      Conserved Domains (1) summary
      pfam01529
      Location:109 → 181
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      32315059..32326032
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030249114.1 → XP_030104974.1  palmitoyltransferase ZDHHC19 isoform X2

      Related
      ENSMUSP00000156284.2, ENSMUST00000231510.2
      Conserved Domains (1) summary
      pfam01529
      Location:26 → 82
      DHHC; DHHC palmitoyltransferase

    2. XM_011245900.1 → XP_011244202.1  palmitoyltransferase ZDHHC19 isoform X1

      UniProtKB/TrEMBL
      B9EIU6
      Conserved Domains (1) summary
      pfam01529
      Location:107 → 179
      DHHC; DHHC palmitoyltransferase

    3. XM_006522135.3 → XP_006522198.1  palmitoyltransferase ZDHHC19 isoform X2

      Conserved Domains (1) summary
      pfam01529
      Location:26 → 82
      DHHC; DHHC palmitoyltransferase

    RNA

    1. XR_875803.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810M5.1 GenPept UniProtKB/Swiss-Prot:Q810M5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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