Gcg glucagon [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gcgprovided by MGI
Official Full Name: glucagonprovided by MGI
Primary source: MGI:MGI:95674
See related: Ensembl:ENSMUSG00000000394 AllianceGenome:MGI:95674
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Glu; PPG; GLP-1
Summary: This gene encodes glucagon, a pancreatic hormone that counteracts the action of insulin in the bloodstream. The encoded protein is processed to generate glucagon and two other glucagon-like peptides, GLP1 and GLP2. Glucagon stimulates gluconeogenesis, glycogenolysis and lipolysis. GLP1 induces secretion of insulin, suppresses glucagon secretion and inhibits feeding. GLP2 induces intestinal absorption of glucose by stimulating the growth of intestinal cells and preventing apoptosis. [provided by RefSeq, Apr 2015]
Expression: Biased expression in large intestine adult (RPKM 20.8), colon adult (RPKM 13.3) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 C1.3; 2 35.85 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (62304874..62313997, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (62474530..62483653, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice.
Title: GLP-1 modulated the firing activity of nigral dopaminergic neurons in both normal and parkinsonian mice.
The crucial relationship between miRNA-27 and CSE/H2S, and the mechanism of action of GLP-1 in myocardial hypertrophy.
Title: The crucial relationship between miRNA-27 and CSE/H(2)S, and the mechanism of action of GLP-1 in myocardial hypertrophy.
Identification of glucagon like peptide-1 (GLP-1) in mice stomach.
Title: Identification of glucagon like peptide-1 (GLP-1) in mice stomach.
Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity.
Title: Renal tubule-specific Atgl deletion links kidney lipid metabolism to glucagon-like peptide 1 and insulin secretion independent of renal inflammation or lipotoxicity.
The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.
Title: The local GLP-1 system in the olfactory bulb is required for odor-evoked cephalic phase of insulin release in mice.
Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents.
Title: Glucagon-Like Peptide-1 Is Involved in the Thermic Effects of Dietary Proteins in Male Rodents.
Upregulated TGF-beta1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling.
Title: Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling.
GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein.
Title: GLP-1 attenuates intestinal fat absorption and chylomicron production via vagal afferent nerves originating in the portal vein.
An inter-organ neural circuit for appetite suppression.
Title: An inter-organ neural circuit for appetite suppression.
Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.
Title: Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.

Submit: New GeneRIF Correction See all GeneRIFs (224)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (10) 1 citation
Targeted (8) 1 citation

General gene information

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Markers

Gcg (e-PCR), detects polymorphism
- UniSTS:507947

Gcg (e-PCR), detects polymorphism
- UniSTS:143186

Gcg (e-PCR), detects polymorphism
- UniSTS:143187

Gcg (e-PCR), detects polymorphism
- UniSTS:525916

Gcg (e-PCR), detects polymorphism
- UniSTS:462684

GCG (e-PCR)
- UniSTS:251485

Gcg (e-PCR), detects polymorphism
- UniSTS:468835

Gcg (e-PCR), detects polymorphism
- UniSTS:256671

Gcg (e-PCR), detects polymorphism
- UniSTS:525223

Gcg (e-PCR), detects polymorphism
- UniSTS:547512

GCG (e-PCR)
- UniSTS:105160

Gcg (e-PCR), detects polymorphism
- UniSTS:105160

Gcg (e-PCR), detects polymorphism
- UniSTS:547834

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables gastric inhibitory polypeptide receptor binding	ISO Inferred from Sequence Orthology more info
enables glucagon receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables glucagon receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucagon stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in glucose homeostasis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of appetite	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of execution phase of apoptosis	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion import	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of gluconeogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-threonine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in response to activity	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in secretory granule lumen	TAS Traceable Author Statement more info

General protein information

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Preferred Names: pro-glucagon

Names: glucagon-like peptide I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.