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    Kifc1 kinesin family member C1 [ Mus musculus (house mouse) ]

    Gene ID: 100502766, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Kifc1provided by MGI
    Official Full Name
    kinesin family member C1provided by MGI
    Primary source
    MGI:MGI:109596
    See related
    Ensembl:ENSMUSG00000079553 AllianceGenome:MGI:109596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HSET; KNSL2; Gm4137; Kifc5a; Knsl2a; Tctex7; Tctex-7; Tctex7a; Tctex-7A; 100042970
    Summary
    Enables minus-end-directed microtubule motor activity. Acts upstream of or within minus-end-directed vesicle transport along microtubule and negative regulation of centrosome duplication. Located in endocytic vesicle; nucleus; and spindle. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E11.5 (RPKM 30.2), liver E14.5 (RPKM 27.2) and 17 other tissues See more
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    Genomic context

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    See Kifc1 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34094640..34109607, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33875664..33890633, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 52316 Neighboring gene uncharacterized LOC118568329 Neighboring gene small integral membrane protein 40, pseudogene Neighboring gene microRNA 6967-2 Neighboring gene STARR-seq mESC enhancer starr_42414 Neighboring gene STARR-positive B cell enhancer ABC_E8918 Neighboring gene small integral membrane protein 40 Neighboring gene STARR-seq mESC enhancer starr_42418 Neighboring gene cDNA sequence BC051226

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes. Wei YL, et al. Exp Cell Res, 2022 May 1. PMID 35259401
    2. Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis. Shan MM, et al. Development, 2022 Mar 1. PMID 35142352
    3. Identification of a novel Leucine-rich repeat protein and candidate PP1 regulatory subunit expressed in developing spermatids. Wang R, et al. BMC Cell Biol, 2008 Jan 31. PMID 18237440, Free PMC Article
    4. Identification of isoforms of a mitotic motor in mammalian spermatogenesis. Navolanic PM, et al. Biol Reprod, 2000 May. PMID 10775188
    5. The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis. Kypri E, et al. Cell Mol Life Sci, 2014 Feb. PMID 23807208, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes.
      Title: Kinesin-14 KIFC1 modulates spindle assembly and chromosome segregation in mouse spermatocytes.
    2. Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
      Title: Kinesin motor KIFC1 is required for tubulin acetylation and actin-dependent spindle migration in mouse oocyte meiosis.
    3. TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
      Title: TRIM8 interacts with KIF11 and KIFC1 and controls bipolar spindle formation and chromosomal stability.
    4. Knockdown of KIFC5A dramatically reduces ciliogenesis.
      Title: The nucleotide-binding proteins Nubp1 and Nubp2 are negative regulators of ciliogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5880, MGC67832, MGC117605

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables minus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within minus-end-directed vesicle transport along microtubule IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic metaphase chromosome alignment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of centrosome duplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vesicle transport along microtubule IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endocytic vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIFC1
    Names
    kinesin family c-terminal 5A
    kinesin motor protein KIFC4
    kinesin-like 2a
    kinesin-related protein KIFC5A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001195298.1 → NP_001182227.1  kinesin-like protein KIFC1 isoform 1

      See identical proteins and their annotated locations for NP_001182227.1

      Status: VALIDATED

      Source sequence(s)
      AI322653, AI326799, AK133900, CX205646, CX209658
      Consensus CDS
      CCDS57065.1
      UniProtKB/Swiss-Prot
      O08671, O35230, Q497Y3, Q4A1N2, Q6PG90, Q8BV06, Q99L84, Q9JKZ0, Q9QWT9
      UniProtKB/TrEMBL
      A0A068BFR6
      Related
      ENSMUSP00000134572.2, ENSMUST00000173492.9
      Conserved Domains (4) summary
      smart00129
      Location:311 → 667
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01366
      Location:309 → 666
      KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins
      pfam15233
      Location:171 → 300
      SYCE1; Synaptonemal complex central element protein 1
      pfam15619
      Location:146 → 306
      Lebercilin; Ciliary protein causing Leber congenital amaurosis disease

    2. NM_001410585.1 → NP_001397514.1  kinesin-like protein KIFC1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      CT030732

    3. NM_001410586.1 → NP_001397515.1  kinesin-like protein KIFC1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      CT030732

    4. NM_001410587.1 → NP_001397516.1  kinesin-like protein KIFC1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT030732

    5. NM_001410588.1 → NP_001397517.1  kinesin-like protein KIFC1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT030732

    RNA

    1. NR_177090.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CT030732

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34094640..34109607 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9QWT9.2 GenPept UniProtKB/Swiss-Prot:Q9QWT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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