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    Tarm1 T cell-interacting, activating receptor on myeloid cells 1 [ Mus musculus (house mouse) ]

    Gene ID: 245126, updated on 8-May-2024

    Summary

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    Official Symbol
    Tarm1provided by MGI
    Official Full Name
    T cell-interacting, activating receptor on myeloid cells 1provided by MGI
    Primary source
    MGI:MGI:2442280
    See related
    Ensembl:ENSMUSG00000053338 AllianceGenome:MGI:2442280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    OLT-2; Gm9904; 9930022N03Rik
    Summary
    Predicted to enable immunoglobulin receptor binding activity. Involved in negative regulation of CD4-positive, alpha-beta T cell proliferation and positive regulation of cytokine production involved in inflammatory response. Located in plasma membrane. Orthologous to human TARM1 (T cell-interacting, activating receptor on myeloid cells 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 1.0), liver E18 (RPKM 0.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tarm1 in Genome Data Viewer
    Location:
    7 A1; 7 2.04 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3535015..3551159, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3486499..3502754, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_17905 Neighboring gene calcium channel, voltage-dependent, gamma subunit 6 Neighboring gene predicted gene, 35037 Neighboring gene predicted gene, 45920 Neighboring gene STARR-seq mESC enhancer starr_17907 Neighboring gene STARR-seq mESC enhancer starr_17908 Neighboring gene STARR-seq mESC enhancer starr_17909 Neighboring gene STARR-seq mESC enhancer starr_17910 Neighboring gene STARR-seq mESC enhancer starr_17911 Neighboring gene osteoclast associated receptor Neighboring gene NADH:ubiquinone oxidoreductase subunit A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens. Yabe R, et al. Nat Commun, 2021 Jan 4. PMID 33397982, Free PMC Article
    2. TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils. Radjabova V, et al. J Immunol, 2015 Oct 1. PMID 26311901, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
      Title: TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens.
    2. The results suggest a putative T cell ligand can interact with TARM1 receptor, resulting in bidirectional signaling and raising the T cell activation threshold while costimulating the release of proinflammatory cytokines by macrophages and neutrophils.
      Title: TARM1 Is a Novel Leukocyte Receptor Complex-Encoded ITAM Receptor That Costimulates Proinflammatory Cytokine Secretion by Macrophages and Neutrophils.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables immunoglobulin receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in immune response-regulating signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of CD4-positive, alpha-beta T cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cytokine production involved in inflammatory response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    T-cell-interacting, activating receptor on myeloid cells protein 1
    Names
    OSCAR-like transcript-2 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362148.1 → NP_001349077.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC240460, AK155804, BY209831
      Consensus CDS
      CCDS90146.1
      UniProtKB/TrEMBL
      A0A0N4SVP3, A0A0R3P9C5
      Related
      ENSMUSP00000145188.2, ENSMUST00000203020.3
      Conserved Domains (1) summary
      cl11960
      Location:126 → 218
      Ig; Immunoglobulin domain

    2. NM_177363.4 → NP_796337.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_796337.1

      Status: VALIDATED

      Source sequence(s)
      AC240460, AK036904, BY209831
      Consensus CDS
      CCDS39727.1
      UniProtKB/Swiss-Prot
      B6A8R8
      UniProtKB/TrEMBL
      A0A0R3P9C5
      Related
      ENSMUSP00000145491.2, ENSMUST00000203821.3
      Conserved Domains (2) summary
      smart00410
      Location:135 → 197
      IG_like; Immunoglobulin like
      cl11960
      Location:27 → 120
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      3535015..3551159 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539980.2 → XP_006540043.1  T-cell-interacting, activating receptor on myeloid cells protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A0R3P9C5
      Conserved Domains (1) summary
      cl11960
      Location:114 → 206
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B6A8R8.1 GenPept UniProtKB/Swiss-Prot:B6A8R8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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