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    Haus8 4HAUS augmin-like complex, subunit 8 [ Mus musculus (house mouse) ]

    Gene ID: 76478, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Haus8provided by MGI
    Official Full Name
    4HAUS augmin-like complex, subunit 8provided by MGI
    Primary source
    MGI:MGI:1923728
    See related
    Ensembl:ENSMUSG00000035439 AllianceGenome:MGI:1923728
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hice1; 2410004L22Rik
    Summary
    Predicted to enable microtubule binding activity. Predicted to be involved in centrosome cycle and spindle assembly. Predicted to act upstream of or within cell division. Predicted to be located in mitotic spindle microtubule. Predicted to be part of HAUS complex. Predicted to be active in centrosome; cytoplasm; and nuclear microtubule. Orthologous to human HAUS8 (HAUS augmin like complex subunit 8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 13.3), liver E14.5 (RPKM 11.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Haus8 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71703241..71725234, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71250597..71272627, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29701 Neighboring gene adenine phosphoribosyl transferase, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E1105 Neighboring gene myosin IXb Neighboring gene STARR-positive B cell enhancer ABC_E6650 Neighboring gene unconventional SNARE in the ER 1 homolog (S. cerevisiae) Neighboring gene occludin/ELL domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
    2. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    3. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
    4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in centrosome cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in centrosome cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spindle assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of HAUS complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitotic spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nuclear microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    HAUS augmin-like complex subunit 8
    Names
    HEC1/NDC80 interacting, centrosome associated 1
    HEC1/NDC80-interacting centrosome-associated protein 1
    sarcoma antigen NY-SAR-48 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163042.1 → NP_001156514.1  HAUS augmin-like complex subunit 8 isoform 1

      See identical proteins and their annotated locations for NP_001156514.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AI837612, BQ177845, CX220280, DV651534
      Consensus CDS
      CCDS52579.1
      UniProtKB/Swiss-Prot
      Q99L00, Q9CWT4
      Related
      ENSMUSP00000040802.7, ENSMUST00000035960.13

    2. NM_001363402.1 → NP_001350331.1  HAUS augmin-like complex subunit 8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC157609, CX226399

    3. NM_001363403.1 → NP_001350332.1  HAUS augmin-like complex subunit 8 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC157609

    4. NM_001363404.1 → NP_001350333.1  HAUS augmin-like complex subunit 8 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC157609, AK161850

    5. NM_001363405.1 → NP_001350334.1  HAUS augmin-like complex subunit 8 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6), as well as variant 7, encodes isoform 6.
      Source sequence(s)
      AC157609

    6. NM_001363406.1 → NP_001350335.1  HAUS augmin-like complex subunit 8 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7), as well as variant 6, encodes isoform 6.
      Source sequence(s)
      AC157609, FO719432

    7. NM_029621.3 → NP_083897.2  HAUS augmin-like complex subunit 8 isoform 2

      See identical proteins and their annotated locations for NP_083897.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is one aa shorter compared to isoform 1.
      Source sequence(s)
      AI837612, AK010398, BQ177845, CX220280
      Consensus CDS
      CCDS22389.1
      UniProtKB/Swiss-Prot
      Q99L00
      Related
      ENSMUSP00000105698.3, ENSMUST00000110071.3

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71703241..71725234 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006509779.5 → XP_006509842.1  HAUS augmin-like complex subunit 8 isoform X1

    2. XM_030243836.2 → XP_030099696.1  HAUS augmin-like complex subunit 8 isoform X3

    3. XM_036154365.1 → XP_036010258.1  HAUS augmin-like complex subunit 8 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99L00.2 GenPept UniProtKB/Swiss-Prot:Q99L00

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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