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    Serpina3f serine (or cysteine) peptidase inhibitor, clade A, member 3F [ Mus musculus (house mouse) ]

    Gene ID: 238393, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Serpina3fprovided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade A, member 3Fprovided by MGI
    Primary source
    MGI:MGI:2182838
    See related
    Ensembl:ENSMUSG00000066363 AllianceGenome:MGI:2182838
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2A1
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Acts upstream of or within response to bacterium; response to cytokine; and response to peptide hormone. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease; cystic fibrosis; and vasculitis. Orthologous to human SERPINA3 (serpin family A member 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in spleen adult (RPKM 2.5), mammary gland adult (RPKM 1.4) and 14 other tissues See more
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    Genomic context

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    See Serpina3f in Genome Data Viewer
    Location:
    12 E; 12 53.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (104180803..104187388)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (104214544..104221129)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3D, pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3E, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4040 Neighboring gene STARR-seq mESC enhancer starr_33133 Neighboring gene developmentally regulated GTP binding protein 2 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade A, member 3G

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The murine Spi-2 proteinase inhibitor locus: a multigene family with a hypervariable reactive site domain. Inglis JD, et al. EMBO J, 1991 Feb. PMID 1991447, Free PMC Article
    2. Expression patterns of murine antichymotrypsin-like genes reflect evolutionary divergence at the Serpina3 locus. Horvath AJ, et al. J Mol Evol, 2004 Oct. PMID 15638460
    3. A review and comparison of the murine alpha1-antitrypsin and alpha1-antichymotrypsin multigene clusters with the human clade A serpins. Forsyth S, et al. Genomics, 2003 Mar. PMID 12659817
    4. APJ Regulates Parallel Alignment of Arteries and Veins in the Skin. Kidoya H, et al. Dev Cell, 2015 May 4. PMID 25920569
    5. Serine protease inhibitors serpina1 and serpina3 are down-regulated in bone marrow during hematopoietic progenitor mobilization. Winkler IG, et al. J Exp Med, 2005 Apr 4. PMID 15795238, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cytokine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to peptide hormone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine protease inhibitor A3F
    Names
    alpha-1 antiproteinasin
    antitrypsin
    serpin A3F

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033335.3 → NP_001028507.2  serine protease inhibitor A3F

      See identical proteins and their annotated locations for NP_001028507.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC142112, AK138954, BC139132
      Consensus CDS
      CCDS26149.1
      UniProtKB/Swiss-Prot
      B2RT49, Q80X76
      UniProtKB/TrEMBL
      Q3UTZ5
      Related
      ENSMUSP00000098641.2, ENSMUST00000101080.2
      Conserved Domains (1) summary
      cd02056
      Location:40 → 405
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    2. NM_001168294.1 → NP_001161766.1  serine protease inhibitor A3F

      See identical proteins and their annotated locations for NP_001161766.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.
      Source sequence(s)
      AC142112, AK138954, AK150157, BC139132
      Consensus CDS
      CCDS26149.1
      UniProtKB/Swiss-Prot
      B2RT49, Q80X76
      UniProtKB/TrEMBL
      Q3UTZ5
      Related
      ENSMUSP00000113945.2, ENSMUST00000121337.8
      Conserved Domains (1) summary
      cd02056
      Location:40 → 405
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    3. NM_001168295.1 → NP_001161767.1  serine protease inhibitor A3F

      See identical proteins and their annotated locations for NP_001161767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC142112, AK138954, AK150157, BC139132
      Consensus CDS
      CCDS26149.1
      UniProtKB/Swiss-Prot
      B2RT49, Q80X76
      UniProtKB/TrEMBL
      Q3UTZ5
      Related
      ENSMUSP00000126520.2, ENSMUST00000167049.8
      Conserved Domains (1) summary
      cd02056
      Location:40 → 405
      alpha-1-antitrypsin_like; alpha-1-antitrypsin_like. This family contains a variety of different members of clade A of the serpin superfamily. They include the classical serine proteinase inhibitors, alpha-1-antitrypsin and alpha-1-antichymotrypsin, protein C inhibitor, ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      104180803..104187388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80X76.3 GenPept UniProtKB/Swiss-Prot:Q80X76

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