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Shh sonic hedgehog signaling molecule [ Rattus norvegicus (Norway rat) ]

Gene ID: 29499, updated on 2-May-2024

Summary

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Official Symbol: Shhprovided by RGD
Official Full Name: sonic hedgehog signaling moleculeprovided by RGD
Primary source: RGD:3673
See related: Ensembl:ENSRNOG00000006120 AllianceGenome:RGD:3673
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ShhNC
Summary: Predicted to enable several functions, including laminin-1 binding activity; metal ion binding activity; and patched binding activity. Involved in several processes, including animal organ development; negative regulation of cell death; and nervous system development. Acts upstream of or within ventral spinal cord interneuron specification. Located in several cellular components, including membrane raft; neuronal cell body; and synaptic vesicle. Used to study Parkinsonism and myocardial infarction. Biomarker of several diseases, including VACTERL association; chronic kidney disease; esophageal atresia/tracheoesophageal fistula; ocular hypertension; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; holoprosencephaly (multiple); hypoplastic or aplastic tibia with polydactyly; middle cerebral artery infarction; and polydactyly. Orthologous to human SHH (sonic hedgehog signaling molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 94.4), Lung (RPKM 38.0) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

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See Shh in Genome Data Viewer

Location:: 4q11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (7687872..7697025)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (6954017..6963170)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (718538..727691, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Title: Sonic hedgehog signaling promotes angiogenesis of endothelial progenitor cells to improve pressure ulcers healing by PI3K/AKT/eNOS signaling.
Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Title: Regulation of Shh/Bmp4 Signaling Pathway by DNA Methylation in Rectal Nervous System Development of Fetal Rats with Anorectal Malformation.
Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells.
Title: Overexpression of sonic hedgehog enhances the osteogenesis in rat ectomesenchymal stem cells.
Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-beta/Smad, NF-kappaB and SHH Signaling Pathway.
Title: Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway.
Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.
Title: Impaired Hedgehog-Gli1 Pathway Activity Underlies the Vascular Phenotype of Polycystic Kidney Disease.
Matrix metalloproteinase-9 regulates the blood brain barrier via the hedgehog pathway in a rat model of traumatic brain injury.
Title: Matrix metalloproteinase-9 regulates the blood brain barrier via the hedgehog pathway in a rat model of traumatic brain injury.
Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.
Title: Regulation of epithelial-mesenchymal transition via sonic hedgehog/glioma-associated oncogene homolog 1 signaling pathway in peritoneal mesothelial cells.
Sonic Hedgehog Regulates Bone Fracture Healing.
Title: Sonic Hedgehog Regulates Bone Fracture Healing.
The Shh/Ptch1 pathway plays an essential role in the model of VD.
Title: DL-3-n-butylphthalide alleviates vascular cognitive impairment by regulating endoplasmic reticulum stress and the Shh/Ptch1 signaling-pathway in rats.
the results of the present study indicated that HG inhibited the Shh pathway in osteoblasts and resulted in patterning defects during osteoblastic differentiation and bone formation, while the activation of Shh signaling could suppress these deleterious effects.
Title: Lentiviral‑mediated Shh reverses the adverse effects of high glucose on osteoblast function and promotes bone formation via Sonic hedgehog signaling.

Submit: New GeneRIF Correction See all GeneRIFs (95)

General gene information

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Markers

Shh (e-PCR), detects polymorphism
- UniSTS:234043

Shh (e-PCR), detects polymorphism
- UniSTS:465494

Shh (e-PCR), detects polymorphism
- UniSTS:238169

Shh (e-PCR), detects polymorphism
- UniSTS:547469

Shh (e-PCR), detects polymorphism
- UniSTS:528041

Shh (e-PCR), detects polymorphism
- UniSTS:547824

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables cholesterol-protein transferase activity	IEA Inferred from Electronic Annotation more info
enables cholesterol-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables cholesterol-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glycosaminoglycan binding	IEA Inferred from Electronic Annotation more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
NOT enables hydrolase activity	ISO Inferred from Sequence Orthology more info
enables laminin-1 binding	IEA Inferred from Electronic Annotation more info
enables laminin-1 binding	ISO Inferred from Sequence Orthology more info
enables laminin-1 binding	ISS Inferred from Sequence or Structural Similarity more info
enables patched binding	IBA Inferred from Biological aspect of Ancestor more info
enables patched binding	IEA Inferred from Electronic Annotation more info
enables patched binding	ISO Inferred from Sequence Orthology more info
enables patched binding	ISS Inferred from Sequence or Structural Similarity more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	ISO Inferred from Sequence Orthology more info
enables peptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Bergmann glial cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Bergmann glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in CD4-positive or CD8-positive, alpha-beta T cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within androgen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in androgen metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in animal organ formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within animal organ formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in artery development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within artery development	ISO Inferred from Sequence Orthology more info
acts_upstream_of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axon guidance	ISO Inferred from Sequence Orthology more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in blood coagulation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within blood coagulation	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in blood vessel morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching involved in prostate gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within branching involved in ureteric bud morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in branching involved in ureteric bud morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within branching morphogenesis of an epithelial tube	ISO Inferred from Sequence Orthology more info
involved_in branching morphogenesis of an epithelial tube	ISS Inferred from Sequence or Structural Similarity more info
involved_in bud outgrowth involved in lung branching	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within bud outgrowth involved in lung branching	ISO Inferred from Sequence Orthology more info
involved_in camera-type eye development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within camera-type eye development	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell development	ISO Inferred from Sequence Orthology more info
involved_in cell development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell fate specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell fate specification	ISO Inferred from Sequence Orthology more info
involved_in cell fate specification	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell proliferation in external granule layer	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell signaling	ISO Inferred from Sequence Orthology more info
involved_in cell-cell signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in cerebellar granule cell precursor proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in cerebellar granule cell precursor proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of left/right asymmetry in lateral mesoderm	IEA Inferred from Electronic Annotation more info
involved_in determination of left/right asymmetry in lateral mesoderm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within determination of left/right symmetry	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth	ISO Inferred from Sequence Orthology more info
involved_in digestive tract mesoderm development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral neural tube patterning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral neural tube patterning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within dorsal/ventral pattern formation	ISO Inferred from Sequence Orthology more info
involved_in dorsal/ventral pattern formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ectoderm development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within ectoderm development	ISO Inferred from Sequence Orthology more info
involved_in embryonic digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digestive tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic digit morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic foregut morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic foregut morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic forelimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic hindlimb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic hindlimb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic limb morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
involved_in embryonic skeletal system development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic skeletal system development	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell proliferation involved in salivary gland morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within epithelial cell proliferation involved in salivary gland morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial tube branching involved in lung morphogenesis	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial-mesenchymal cell signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial-mesenchymal signaling involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in establishment of epithelial cell polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of epithelial cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in forebrain development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within forebrain regionalization	ISO Inferred from Sequence Orthology more info
involved_in formation of anatomical boundary	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within formation of anatomical boundary	ISO Inferred from Sequence Orthology more info
involved_in fungiform papilla development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungiform papilla formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fungiform papilla morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hair follicle development	ISO Inferred from Sequence Orthology more info
involved_in hair follicle morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hair follicle morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
involved_in heart development	ISS Inferred from Sequence or Structural Similarity more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
involved_in heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hindbrain development	ISO Inferred from Sequence Orthology more info
involved_in hindbrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in hindgut morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hindgut morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inner ear development	ISO Inferred from Sequence Orthology more info
involved_in intein-mediated protein splicing	IEA Inferred from Electronic Annotation more info
involved_in intermediate filament organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intermediate filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
involved_in left lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within left lung development	ISO Inferred from Sequence Orthology more info
involved_in limb bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within limb bud formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within limb development	ISO Inferred from Sequence Orthology more info
involved_in liver regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
involved_in lung development	ISS Inferred from Sequence or Structural Similarity more info
involved_in lung epithelium development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung epithelium development	ISO Inferred from Sequence Orthology more info
involved_in lung lobe morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung lobe morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in lung-associated mesenchyme development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in lymphoid progenitor cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in lymphoid progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in lymphoid progenitor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in male genitalia development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within male genitalia development	ISO Inferred from Sequence Orthology more info
involved_in male genitalia development	ISS Inferred from Sequence or Structural Similarity more info
involved_in male genitalia morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mesenchymal cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell proliferation involved in lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal cell proliferation involved in lung development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal smoothened signaling pathway involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal smoothened signaling pathway involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in metanephric collecting duct development	IEA Inferred from Electronic Annotation more info
involved_in metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchymal cell proliferation involved in metanephros development	IEA Inferred from Electronic Annotation more info
involved_in metanephric mesenchymal cell proliferation involved in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephric mesenchymal cell proliferation involved in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in metanephros development	ISO Inferred from Sequence Orthology more info
involved_in metanephros development	ISS Inferred from Sequence or Structural Similarity more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within midbrain development	ISO Inferred from Sequence Orthology more info
involved_in midbrain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in myoblast differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within myoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within myotube differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cholesterol efflux	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol efflux	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of dopaminergic neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of kidney smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of kidney smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of kidney smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of mesenchymal cell apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription elongation by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ureter smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of ureter smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ureter smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in negative thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in negative thymic T cell selection	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural crest cell migration	ISO Inferred from Sequence Orthology more info
involved_in neural crest cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuroblast proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron fate commitment	ISO Inferred from Sequence Orthology more info
involved_in neuron fate commitment	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in odontogenesis of dentin-containing tooth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within oligodendrocyte development	ISO Inferred from Sequence Orthology more info
involved_in oligodendrocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in osteoblast development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within osteoblast development	ISO Inferred from Sequence Orthology more info
involved_in pancreas development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pancreas development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within pattern specification process	ISO Inferred from Sequence Orthology more info
involved_in pattern specification process	ISS Inferred from Sequence or Structural Similarity more info
involved_in polarity specification of anterior/posterior axis	IEA Inferred from Electronic Annotation more info
involved_in polarity specification of anterior/posterior axis	ISO Inferred from Sequence Orthology more info
involved_in polarity specification of anterior/posterior axis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell differentiation in thymus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell differentiation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of alpha-beta T cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of alpha-beta T cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of astrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell division	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cerebellar granule cell precursor proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cerebellar granule cell precursor proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell chemotaxis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of epithelial cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immature T cell proliferation in thymus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immature T cell proliferation in thymus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of immature T cell proliferation in thymus	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of kidney smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of kidney smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kidney smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mesenchymal cell proliferation involved in ureter development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuroblast proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neurotrophin production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oligodendrocyte differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of oligodendrocyte progenitor proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of penile erection	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of photoreceptor cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sclerotome development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of sclerotome development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of skeletal muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of sprouting angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureter smooth muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ureter smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ureter smooth muscle cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive thymic T cell selection	IEA Inferred from Electronic Annotation more info
involved_in positive thymic T cell selection	ISO Inferred from Sequence Orthology more info
involved_in positive thymic T cell selection	ISS Inferred from Sequence or Structural Similarity more info
involved_in primary prostatic bud elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primary prostatic bud elongation	ISO Inferred from Sequence Orthology more info
involved_in prostate epithelial cord elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostate epithelial cord elongation	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in prostate gland development	ISS Inferred from Sequence or Structural Similarity more info
NOT acts_upstream_of_or_within prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in protein autoprocessing	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of epithelial cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of epithelial cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of glial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of mesenchymal cell proliferation involved in prostate gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mesenchymal cell proliferation involved in prostate gland development	ISO Inferred from Sequence Orthology more info
involved_in regulation of odontogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of odontogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of prostatic bud formation	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within respiratory tube development	ISO Inferred from Sequence Orthology more info
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ethanol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in right lung development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within right lung development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in salivary gland cavitation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within salivary gland cavitation	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	IEA Inferred from Electronic Annotation more info
involved_in self proteolysis	ISO Inferred from Sequence Orthology more info
involved_in self proteolysis	ISS Inferred from Sequence or Structural Similarity more info
involved_in skeletal muscle cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of skeletal muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle fiber differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal muscle fiber differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of skeletal muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle tissue development	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in smoothened signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in somite development	IEA Inferred from Electronic Annotation more info
involved_in somite development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	IDA Inferred from Direct Assay more info	PubMed
involved_in spinal cord dorsal/ventral patterning	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord dorsal/ventral patterning	ISO Inferred from Sequence Orthology more info
involved_in spinal cord motor neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within spinal cord motor neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell development	ISO Inferred from Sequence Orthology more info
involved_in stem cell development	ISS Inferred from Sequence or Structural Similarity more info
involved_in stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within striated muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in striated muscle tissue development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within striated muscle tissue development	ISO Inferred from Sequence Orthology more info
involved_in telencephalon regionalization	IEA Inferred from Electronic Annotation more info
involved_in telencephalon regionalization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within telencephalon regionalization	ISO Inferred from Sequence Orthology more info
involved_in thalamus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thalamus development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	IEA Inferred from Electronic Annotation more info
involved_in thymus development	ISO Inferred from Sequence Orthology more info
involved_in thymus development	ISS Inferred from Sequence or Structural Similarity more info
involved_in thyroid gland development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within thyroid gland development	ISO Inferred from Sequence Orthology more info
involved_in tongue development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tongue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trachea development	ISO Inferred from Sequence Orthology more info
involved_in trachea morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within trachea morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in tracheoesophageal septum formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tracheoesophageal septum formation	ISO Inferred from Sequence Orthology more info
involved_in trunk neural crest cell migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of trunk neural crest cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within ventral spinal cord interneuron specification	IDA Inferred from Direct Assay more info	PubMed
involved_in zona limitans intrathalamica formation	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane raft	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: sonic hedgehog protein

Names: shh unprocessed N-terminal signaling and C-terminal autoprocessing domains; sonic hedgehog homolog

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017221.1 → NP_058917.1 sonic hedgehog protein precursor

See identical proteins and their annotated locations for NP_058917.1

Status: PROVISIONAL

Source sequence(s)

L27340

UniProtKB/Swiss-Prot

Q63673

UniProtKB/TrEMBL

A6KJL6, G3V6T0

Related

ENSRNOP00000008497.1, ENSRNOT00000008497.3

Conserved Domains (3) summary

cd00081
Location:199 → 349

Hint; Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein, ...

pfam01079
Location:188 → 423

Hint; Hint module

pfam01085
Location:40 → 185

HH_signal; Hedgehog amino-terminal signalling domain