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    Mug1l1 murinoglobulin 1 like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297568, updated on 2-May-2024

    Summary

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    Official Symbol
    Mug1l1provided by RGD
    Official Full Name
    murinoglobulin 1 like 1provided by RGD
    Primary source
    RGD:1584999
    See related
    Ensembl:ENSRNOG00000070375 AllianceGenome:RGD:1584999
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A1i3; alpha-1-I3
    Summary
    Predicted to enable endopeptidase inhibitor activity and protease binding activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in extracellular space. Orthologous to human PZP (PZP alpha-2-macroglobulin like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Restricted expression toward (RPKM 13951.4) See more
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    Genomic context

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    See Mug1l1 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (156652355..156708771)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (154980279..155036688)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (154505736..154565104)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene voltage-dependent anion channel 2, pseudogene 4 Neighboring gene alpha-2-macroglobulin Neighboring gene thymosin beta-10 pseudogene Neighboring gene salvador family WW domain containing protein 1, pseudogene 1 Neighboring gene murinoglobulin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structure and negative transcriptional regulation by glucocorticoids of the acute-phase rat alpha 1-inhibitor III gene. Northemann W, et al. Biochemistry, 1989 Jan 10. PMID 2495816
    2. Proteinase binding and inhibition by the monomeric alpha-macroglobulin rat alpha 1-inhibitor-3. Enghild JJ, et al. J Biol Chem, 1989 Jul 5. PMID 2472396
    3. Sequence and acute phase regulation of rat alpha 1-inhibitor III messenger RNA. Braciak TA, et al. J Biol Chem, 1988 Mar 15. PMID 2831216
    4. Identification and sequencing of cDNA clones for the rodent negative acute-phase protein alpha 1-inhibitor 3. Schweizer M, et al. Eur J Biochem, 1987 Apr 15. PMID 2436907
    5. The sclerostin-bone protein interactome. Devarajan-Ketha H, et al. Biochem Biophys Res Commun, 2012 Jan 13. PMID 22206666, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1-inhibitor 3
    Names
    alpha-1-inhibitor III
    murinoglobulin-2-like

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037975.2 → NP_001033064.2  alpha-1-inhibitor 3 precursor

      See identical proteins and their annotated locations for NP_001033064.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      P14046, Q4G042, Q63266, Q6LDP2, Q6LDR8
      UniProtKB/TrEMBL
      A0A0G2K926, A6ILD3
      Related
      ENSRNOP00000074833.1, ENSRNOT00000081488.2
      Conserved Domains (6) summary
      cd02897
      Location:961 → 1267
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:741 → 831
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1379 → 1466
      A2M_recep; A-macroglobulin receptor
      pfam07678
      Location:1014 → 1269
      A2M_comp; A-macroglobulin complement component
      pfam07703
      Location:459 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      156652355..156708771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039107437.2 → XP_038963365.1  alpha-1-inhibitor 3 isoform X1

      UniProtKB/Swiss-Prot
      P14046, Q4G042, Q63266, Q6LDP2, Q6LDR8
      Related
      ENSRNOP00000077625.1
      Conserved Domains (7) summary
      cd02897
      Location:961 → 1267
      A2M_2; Proteins similar to alpha2-macroglobulin (alpha (2)-M). This group also contains the pregnancy zone protein (PZP). Alpha(2)-M and PZP are broadly specific proteinase inhibitors. Alpha (2)-M is a major carrier protein in serum. The structural thioester ...
      pfam00207
      Location:741 → 831
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07677
      Location:1379 → 1466
      A2M_recep; A-macroglobulin receptor
      pfam07703
      Location:457 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3

    2. XM_039107439.2 → XP_038963367.1  alpha-1-inhibitor 3 isoform X2

      Conserved Domains (6) summary
      pfam00207
      Location:741 → 831
      A2M; Alpha-2-macroglobulin family
      pfam01835
      Location:129 → 221
      A2M_N; MG2 domain
      pfam07703
      Location:457 → 606
      A2M_N_2; Alpha-2-macroglobulin family N-terminal region
      pfam17789
      Location:348 → 443
      MG4; Macroglobulin domain MG4
      pfam17791
      Location:223 → 309
      MG3; Macroglobulin domain MG3
      cl08267
      Location:961 → 1125
      ISOPREN_C2_like; This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P14046.1 GenPept UniProtKB/Swiss-Prot:P14046

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