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    Adprhl1 ADP-ribosylhydrolase like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290880, updated on 6-Jun-2024

    Summary

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    Symbol
    Adprhl1provided by RGD
    Full Name
    ADP-ribosylhydrolase like 1provided by RGD
    Primary source
    RGD:1305641
    See related
    Ensembl:ENSRNOG00000019504 AllianceGenome:RGD:1305641
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    AABR07026536.1
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Orthologous to human ADPRHL1 (ADP-ribosylhydrolase like 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 271.3), Muscle (RPKM 109.8) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Adprhl1 in Genome Data Viewer
    Location:
    16q12.5
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (82985355..83017240)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (76283186..76315075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (81616098..81648133)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene uncharacterized LOC102548530 Neighboring gene microtubule-associated protein 1 light chain 3 beta, pseudogene 1 Neighboring gene uncharacterized LOC102548586

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Interacting Network of the Gap Junction (GJ) Protein Connexin43 (Cx43) is Modulated by Ischemia and Reperfusion in the Heart. Martins-Marques T, et al. Mol Cell Proteomics, 2015 Nov. PMID 26316108, Free PMC Article
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ADP-ribosylarginine hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, hydrolyzing N-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cardiac chamber ballooning ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cardiac myofibril assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in sarcomere IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcomere ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    inactive ADP-ribosyltransferase ARH2
    Names
    ADP-ribosylhydrolase 2
    ADP-ribosylhydrolase-like protein 1
    [Protein ADP-ribosylarginine] hydrolase-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013054.2 → NP_001013072.1  inactive ADP-ribosyltransferase ARH2 isoform 1

      See identical proteins and their annotated locations for NP_001013072.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/Swiss-Prot
      Q5XIB3
      UniProtKB/TrEMBL
      A0A8L2QE10, A6IWI7
      Related
      ENSRNOP00000026391.7, ENSRNOT00000026392.9
      Conserved Domains (1) summary
      pfam03747
      Location:6 → 326
      ADP_ribosyl_GH; ADP-ribosylglycohydrolase

    2. NM_001409008.1 → NP_001395937.1  inactive ADP-ribosyltransferase ARH2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000016
      UniProtKB/TrEMBL
      A0A8J8XAN4
      Related
      ENSRNOP00000054552.5, ENSRNOT00000057740.6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      82985355..83017240
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275261.1 → XP_063131331.1  inactive ADP-ribosyltransferase ARH2 isoform X1

    2. XM_039095253.2 → XP_038951181.1  inactive ADP-ribosyltransferase ARH2 isoform X1

      Conserved Domains (1) summary
      PHA03247
      Location:949 → 1315
      PHA03247; large tegument protein UL36; Provisional
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XIB3.1 GenPept UniProtKB/Swiss-Prot:Q5XIB3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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