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    Folh1 folate hydrolase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 85309, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Folh1provided by RGD
    Official Full Name
    folate hydrolase 1provided by RGD
    Primary source
    RGD:70963
    See related
    Ensembl:ENSRNOG00000013770 AllianceGenome:RGD:70963
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Naalad
    Summary
    Predicted to enable Ac-Asp-Glu binding activity; exopeptidase activity; and tetrahydrofolyl-poly(glutamate) polymer binding activity. Involved in positive regulation of apoptotic process and proteolysis. Predicted to be located in cell surface. Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including FOLH1 (folate hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 251.5) and Brain (RPKM 88.9) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Folh1 in Genome Data Viewer
    Location:
    1q32
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (149828286..149914313, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (140428101..140501563, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (150323768..150395415, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 14 subfamily A member 261, pseudogene 1 Neighboring gene olfactory receptor family 14 subfamily C member 39 Neighboring gene twinkle protein, mitochondrial pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 66 Neighboring gene vomeronasal 2 receptor, pseudogene 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia. Zuo D, et al. J Biol Chem, 2012 Jun 22. PMID 22570482, Free PMC Article
    2. N-Acetylated alpha-linked acidic dipeptidase expressed in rat adipocytes is localized in the insulin-responsive glucose transporter (GLUT4) intracellular compartments and involved in the insulin-stimulated GLUT4 recruitment. Park SY, et al. Arch Biochem Biophys, 2004 Apr 1. PMID 15019832
    3. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models. Ghadge GD, et al. Proc Natl Acad Sci U S A, 2003 Aug 5. PMID 12876198, Free PMC Article
    4. Isolation and expression of a rat brain cDNA encoding glutamate carboxypeptidase II. Luthi-Carter R, et al. Proc Natl Acad Sci U S A, 1998 Mar 17. PMID 9501243, Free PMC Article
    5. Molecular cloning of a peptidase against N-acetylaspartylglutamate from a rat hippocampal cDNA library. Bzdega T, et al. J Neurochem, 1997 Dec. PMID 9375657

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Folh1 gene plays an important role in folate and sulfur amino acid levels and affects glucose and lipid metabolism in the rat.
      Title: Dissecting the role of Folr1 and Folh1 genes in the pathogenesis of metabolic syndrome in spontaneously hypertensive rats.
    2. NAAG peptidase inhibition has a role in release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia
      Title: Effects of N-acetylaspartylglutamate (NAAG) peptidase inhibition on release of glutamate and dopamine in prefrontal cortex and nucleus accumbens in phencyclidine model of schizophrenia.
    3. Tissues such as prostate and testes exhibit different GCPII expression levels among the species studied (human, rats, swine).
      Title: Tissue expression and enzymologic characterization of human prostate specific membrane antigen and its rat and pig orthologs.
    4. role of glutamate carboxypeptidase II inhibition in preventing programmed cell death in neurons exposed to high glucose; this neuroprotection is mediated through the mGluR3 receptor, most likely by increasing the extracellular NAAG concentration
      Title: Protection against glucose-induced neuronal death by NAAG and GCP II inhibition is regulated by mGluR3.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables Ac-Asp-Glu binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxypeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carboxypeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dipeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dipeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallocarboxypeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tetrahydrofolyl-poly(glutamate) polymer binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within folic acid-containing compound metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamate carboxypeptidase 2
    Names
    FGCP
    GCPII
    N-acetylated alpha-linked acidic dipeptidase
    N-acetylated-alpha-linked acidic dipeptidase I
    NAALADase I
    folylpoly-gamma-glutamate carboxypeptidase
    glutamate carboxypeptidase II
    mGCP
    membrane glutamate carboxypeptidase
    prostate-specific membrane antigen homolog
    pteroylpoly-gamma-glutamate carboxypeptidase
    NP_476533.2
    XP_038948866.1
    XP_063131972.1
    XP_063131974.1
    XP_063131977.1
    XP_063131978.1
    XP_063131979.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_057185.3 → NP_476533.2  glutamate carboxypeptidase 2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      P70627, Q547B6
      UniProtKB/TrEMBL
      A6I5Y1, G3V7S0
      Related
      ENSRNOP00000018592.3, ENSRNOT00000018592.4
      Conserved Domains (4) summary
      cd02121
      Location:122 → 348
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:356 → 597
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:629 → 749
      TFR_dimer; Transferrin receptor-like dimerization domain
      cl14876
      Location:60 → 117
      Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      149828286..149914313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063275902.1 → XP_063131972.1  glutamate carboxypeptidase 2 isoform X1

      UniProtKB/Swiss-Prot
      P70627, Q547B6
      UniProtKB/TrEMBL
      A6I5Y1, G3V7S0

    2. XM_063275904.1 → XP_063131974.1  glutamate carboxypeptidase 2 isoform X1

      UniProtKB/Swiss-Prot
      P70627, Q547B6
      UniProtKB/TrEMBL
      A6I5Y1, G3V7S0

    3. XM_039092938.2 → XP_038948866.1  glutamate carboxypeptidase 2 isoform X2

      UniProtKB/Swiss-Prot
      P70627, Q547B6
      Conserved Domains (3) summary
      cd02121
      Location:14 → 222
      PA_GCPII_like; Protease-associated domain containing protein, glutamate carboxypeptidase II (GCPII)-like. This group contains various PA domain-containing proteins similar to GCPII including, GCPIII (NAALADase2) and NAALADase L. These proteins belong to the peptidase ...
      cd08022
      Location:230 → 471
      M28_PSMA_like; M28 Zn-peptidase prostate-specific membrane antigen
      pfam04253
      Location:503 → 623
      TFR_dimer; Transferrin receptor-like dimerization domain

    4. XM_063275909.1 → XP_063131979.1  glutamate carboxypeptidase 2 isoform X4

    5. XM_063275907.1 → XP_063131977.1  glutamate carboxypeptidase 2 isoform X3

    6. XM_063275908.1 → XP_063131978.1  glutamate carboxypeptidase 2 isoform X4

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P70627.1 GenPept UniProtKB/Swiss-Prot:P70627

    Gene LinkOut

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