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    tobi target of brain insulin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43072, updated on 10-May-2024

    Summary

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    Official Symbol
    tobiprovided by FlyBase
    Official Full Name
    target of brain insulinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261575
    Locus tag
    Dmel_CG11909
    See related
    AllianceGenome:FB:FBgn0261575
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11909; CT33098; Dmel\CG11909; Tobi
    Summary
    Predicted to enable hydrolase activity, hydrolyzing O-glycosyl compounds. Predicted to be involved in carbohydrate metabolic process. Is expressed in adult gut; adult head; and fat cell. Human ortholog(s) of this gene implicated in basal ganglia calcification. Orthologous to human MYORG (myogenesis regulating glycosidase (putative)). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See tobi in Genome Data Viewer
    Location:
    96D2-96D2; 3-87 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25344761..25346921, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21170483..21172643, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene rha Neighboring gene Furin 1 Neighboring gene NADH dehydrogenase (ubiquinone) 49 kDa subunit-like Neighboring gene astrocytic leucine-rich repeat molecule

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Statin Target Hmgcr Regulates Energy Metabolism and Food Intake through Central Mechanisms. Williams MJ, et al. Cells, 2022 Mar 11. PMID 35326421, Free PMC Article
    2. Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila. Strilbytska OM, et al. Front Physiol, 2020. PMID 33391017, Free PMC Article
    3. Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues. Zhang S, et al. Int J Mol Sci, 2018 Apr 10. PMID 29642630, Free PMC Article
    4. Insulin Signaling in Intestinal Stem and Progenitor Cells as an Important Determinant of Physiological and Metabolic Traits in Drosophila. Strilbytska OM, et al. Cells, 2020 Mar 26. PMID 32225024, Free PMC Article
    5. The Neuropeptide Allatostatin A Regulates Metabolism and Feeding Decisions in Drosophila. Hentze JL, et al. Sci Rep, 2015 Jun 30. PMID 26123697, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    target of brain insulin
    Names
    CG11909-PA
    alpha-Glucosidase
    tobi-PA
    NP_651391.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25344761..25346921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143134.3 → NP_651391.1  target of brain insulin [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651391.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VBR6
      Related
      FBpp0084221
      Conserved Domains (2) summary
      cd06592
      Location:255 → 621
      GH31_NET37; glucosidase NET37
      pfam01055
      Location:246 → 653
      Glyco_hydro_31; Glycosyl hydrolases family 31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VBR6 Q9VBR6

    Gene LinkOut

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