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    CG9331 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35347, updated on 10-May-2024

    Summary

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    Official Symbol
    CG9331provided by FlyBase
    Primary source
    FLYBASE:FBgn0032889
    Locus tag
    Dmel_CG9331
    See related
    AllianceGenome:FB:FBgn0032889
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG9331; GRHPR
    Summary
    Predicted to enable glycerate dehydrogenase activity; glyoxylate reductase (NADP+) activity; and hydroxypyruvate reductase activity. Located in extracellular region. Is expressed in several structures, including adult head; adult heart; embryonic epidermis; embryonic/larval midgut; and yolk nucleus. Human ortholog(s) of this gene implicated in primary hyperoxaluria and primary hyperoxaluria type 2. Orthologous to human GRHPR (glyoxylate and hydroxypyruvate reductase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See CG9331 in Genome Data Viewer
    Location:
    38F1-38F1; 2-54 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20822828..20827744)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20822828..20827744)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Chemosensory protein B 38a Neighboring gene Chemosensory protein B 38c Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Outer segment 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamic reprogramming of chromatin accessibility during Drosophila embryo development. Thomas S, et al. Genome Biol, 2011. PMID 21569360, Free PMC Article
    2. Macrophage mitochondrial bioenergetics and tissue invasion are boosted by an Atossa-Porthos axis in Drosophila. Emtenani S, et al. EMBO J, 2022 Jun 14. PMID 35319107, Free PMC Article
    3. Shared Genetic Signals of Hypoxia Adaptation in Drosophila and in High-Altitude Human Populations. Jha AR, et al. Mol Biol Evol, 2016 Feb. PMID 26576852, Free PMC Article
    4. Proteomic mapping in live Drosophila tissues using an engineered ascorbate peroxidase. Chen CL, et al. Proc Natl Acad Sci U S A, 2015 Sep 29. PMID 26362788, Free PMC Article
    5. Proteomic analysis of the Drosophila larval hemolymph clot. Karlsson C, et al. J Biol Chem, 2004 Dec 10. PMID 15466469

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycerate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxypyruvate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region HDA PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG9331-PA
    CG9331-PB
    CG9331-PC
    CG9331-PD
    CG9331-PF
    CG9331-PG
    CG9331-PH
    CG9331-PI
    CG9331-PJ
    CG9331-PK
    CG9331-PL
    CG9331-PM
    NP_001188857.1
    NP_001188858.1
    NP_001188859.1
    NP_001188860.1
    NP_001286107.1
    NP_001286108.1
    NP_001286109.1
    NP_610062.2
    NP_724293.2
    NP_788080.1
    NP_788081.1
    NP_995737.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      20822828..20827744
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299179.1 → NP_001286108.1  uncharacterized protein Dmel_CG9331, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286108.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    2. NM_001299178.1 → NP_001286107.1  uncharacterized protein Dmel_CG9331, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286107.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q8SZU0
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    3. NM_176066.4 → NP_788080.1  uncharacterized protein Dmel_CG9331, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788080.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q8SZU0
      Related
      FBpp0080949
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    4. NM_001201928.2 → NP_001188857.1  uncharacterized protein Dmel_CG9331, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188857.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    5. NM_001201931.2 → NP_001188860.1  uncharacterized protein Dmel_CG9331, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q8SZU0
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    6. NM_206015.3 → NP_995737.2  uncharacterized protein Dmel_CG9331, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995737.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    7. NM_001201930.2 → NP_001188859.1  uncharacterized protein Dmel_CG9331, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188859.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q8SZU0
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    8. NM_001201929.2 → NP_001188858.1  uncharacterized protein Dmel_CG9331, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188858.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    9. NM_176067.3 → NP_788081.1  uncharacterized protein Dmel_CG9331, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788081.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Related
      FBpp0080948
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    10. NM_136218.4 → NP_610062.2  uncharacterized protein Dmel_CG9331, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610062.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q7KT11, Q7KT12
      Related
      FBpp0080946
      Conserved Domains (2) summary
      COG1052
      Location:8 → 320
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:8 → 318
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    11. NM_001299180.1 → NP_001286109.1  uncharacterized protein Dmel_CG9331, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286109.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q9VIJ0
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

    12. NM_165345.3 → NP_724293.2  uncharacterized protein Dmel_CG9331, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724293.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6TP73, Q9VIJ0
      Related
      FBpp0080947
      Conserved Domains (2) summary
      COG1052
      Location:46 → 358
      LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
      cd05301
      Location:46 → 356
      GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KT11 Q7KT11
    Q8SZU0 Q8SZU0
    Q9VIJ0 Q9VIJ0

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