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    Cd19 CD19 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 365367, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Cd19provided by RGD
    Official Full Name
    CD19 moleculeprovided by RGD
    Primary source
    RGD:1309086
    See related
    Ensembl:ENSRNOG00000018311 AllianceGenome:RGD:1309086
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in several processes, including B cell activation; B cell receptor signaling pathway; and positive regulation of phosphatidylinositol 3-kinase activity. Predicted to act upstream of or within positive regulation of release of sequestered calcium ion into cytosol. Predicted to be integral component of plasma membrane. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 430.5) and Thymus (RPKM 64.7) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cd19 in Genome Data Viewer
    Location:
    1q36
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (190417853..190424494, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (180987286..180993920, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (197815422..197822123, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 2 interacting protein Neighboring gene ribosomal protein L36 like 3 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 Neighboring gene SH2B adaptor protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. An antibody-deficiency syndrome due to mutations in the CD19 gene. van Zelm MC, et al. N Engl J Med, 2006 May 4. PMID 16672701
    2. Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice. Rickert RC, et al. Nature, 1995 Jul 27. PMID 7543183
    3. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Carter RH, et al. Science, 1992 Apr 3. PMID 1373518
    4. Qualitative regulation of B cell antigen receptor signaling by CD19: selective requirement for PI3-kinase activation, inositol-1,4,5-trisphosphate production and Ca2+ mobilization. Buhl AM, et al. J Exp Med, 1997 Dec 1. PMID 9382888, Free PMC Article
    5. The actin and tetraspanin networks organize receptor nanoclusters to regulate B cell receptor-mediated signaling. Mattila PK, et al. Immunity, 2013 Mar 21. PMID 23499492

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC109570

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in B cell mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell proliferation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in B-1 B cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen receptor-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in immunoglobulin mediated immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of B cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    B-lymphocyte antigen CD19
    Names
    CD19 antigen

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013237.4 → NP_001013255.2  B-lymphocyte antigen CD19 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A6I950
      Conserved Domains (2) summary
      cd00096
      Location:190 → 198
      Ig; Ig strand B [structural motif]
      cl11960
      Location:185 → 284
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      190417853..190424494 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039085264.2 → XP_038941192.1  B-lymphocyte antigen CD19 isoform X1

      UniProtKB/TrEMBL
      A6I950
      Conserved Domains (2) summary
      cd00096
      Location:190 → 198
      Ig; Ig strand B [structural motif]
      cl11960
      Location:185 → 284
      Ig; Immunoglobulin domain

    2. XM_006230316.5 → XP_006230378.1  B-lymphocyte antigen CD19 isoform X2

      UniProtKB/TrEMBL
      A6I950
      Related
      ENSRNOP00000051906.3
      Conserved Domains (2) summary
      smart00410
      Location:26 → 115
      IG_like; Immunoglobulin like
      cl11960
      Location:23 → 118
      Ig; Immunoglobulin domain

    3. XM_039085277.1 → XP_038941205.1  B-lymphocyte antigen CD19 isoform X3

    4. XM_039085283.2 → XP_038941211.1  B-lymphocyte antigen CD19 isoform X3

    5. XM_063269515.1 → XP_063125585.1  B-lymphocyte antigen CD19 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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