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    Map4k3 mitogen-activated protein kinase kinase kinase kinase 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 170920, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Map4k3provided by RGD
    Official Full Name
    mitogen-activated protein kinase kinase kinase kinase 3provided by RGD
    Primary source
    RGD:621280
    See related
    Ensembl:ENSRNOG00000007172 AllianceGenome:RGD:621280
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables SH3 domain binding activity. Predicted to be involved in several processes, including protein phosphorylation; response to UV; and response to tumor necrosis factor. Orthologous to human MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 225.0), Lung (RPKM 194.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Map4k3 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (20029246..20198583)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (14276623..14446321)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (3276732..3444519, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479322 Neighboring gene uncharacterized LOC102551891 Neighboring gene eukaryotic translation initiation factor 1-like Neighboring gene cyclin-dependent kinase-like 4 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene SOS Ras/Rac guanine nucleotide exchange factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation. Guo CY, et al. Med Sci Monit, 2017 Jul 21. PMID 28731988, Free PMC Article
    2. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Diener K, et al. Proc Natl Acad Sci U S A, 1997 Sep 2. PMID 9275185, Free PMC Article
    3. Enhancement of chondrocyte autophagy is an early response in the degenerative cartilage of the temporomandibular joint to biomechanical dental stimulation. Zhang M, et al. Apoptosis, 2013 Apr. PMID 23386193
    4. Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase. Ramjaun AR, et al. J Biol Chem, 2001 Aug 3. PMID 11384986
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MAP4K3 positively regulates preterm skeletal muscle satellite cell myogenesis, but may not regulate mTORC1 activity. MAP4K3 may play a role in mTORC1 full activation in response to leucine.
      Title: Roles of Mitogen-Activating Protein Kinase Kinase Kinase Kinase-3 (MAP4K3) in Preterm Skeletal Muscle Satellite Cell Myogenesis and Mammalian Target of Rapamycin Complex 1 (mTORC1) Activation Regulation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables MAP kinase kinase kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to UV IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to UV ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to UV ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to tumor necrosis factor IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to tumor necrosis factor ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mitogen-activated protein kinase kinase kinase kinase 3
    Names
    GLK
    MAPK/ERK kinase kinase kinase 3
    MEK kinase kinase 3
    MEKKK 3
    germinal center kinase-related protein kinase
    NP_596898.1
    XP_006239718.2
    XP_017449508.2
    XP_017449509.2
    XP_017449510.2
    XP_038967654.1
    XP_038967655.1
    XP_038967656.1
    XP_038967657.1
    XP_038967658.1
    XP_038967659.1
    XP_038967660.1
    XP_038967661.1
    XP_063117574.1
    XP_063117575.1
    XP_063117576.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133407.1 → NP_596898.1  mitogen-activated protein kinase kinase kinase kinase 3

      See identical proteins and their annotated locations for NP_596898.1

      Status: VALIDATED

      Source sequence(s)
      AA819812, AF312224, AI502900, CK474868, DV716943
      UniProtKB/Swiss-Prot
      Q924I2
      UniProtKB/TrEMBL
      A6H9Q1, R9PXT4
      Related
      ENSRNOP00000010366.7, ENSRNOT00000010366.8
      Conserved Domains (3) summary
      smart00036
      Location:540 → 853
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      smart00220
      Location:16 → 273
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      20029246..20198583
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039111726.2 → XP_038967654.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:583 → 926
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    2. XM_039111728.2 → XP_038967656.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X4

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:562 → 905
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    3. XM_039111729.2 → XP_038967657.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X6

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:583 → 896
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    4. XM_039111727.2 → XP_038967655.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:572 → 915
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    5. XM_017594019.3 → XP_017449508.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AV17
      Conserved Domains (2) summary
      smart00036
      Location:572 → 915
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    6. XM_017594021.3 → XP_017449510.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X7

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:551 → 894
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    7. XM_017594020.3 → XP_017449509.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AV17
      Related
      ENSRNOP00000090754.1
      Conserved Domains (2) summary
      smart00036
      Location:561 → 904
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    8. XM_063261505.1 → XP_063117575.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X9

    9. XM_063261504.1 → XP_063117574.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X8

    10. XM_006239656.5 → XP_006239718.2  mitogen-activated protein kinase kinase kinase kinase 3 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JVZ8, A0A8I6AV17
      Related
      ENSRNOP00000069683.2
      Conserved Domains (2) summary
      smart00036
      Location:561 → 874
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    11. XM_039111730.2 → XP_038967658.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X11

      UniProtKB/TrEMBL
      R9PXT4
      Conserved Domains (2) summary
      smart00036
      Location:551 → 864
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:15 → 273
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    12. XM_039111731.2 → XP_038967659.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X12

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:520 → 863
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cd06613
      Location:1 → 210
      STKc_MAP4K3_like; Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases

    13. XM_039111732.1 → XP_038967660.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:494 → 837
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 184
      PKc_like; Protein Kinases, catalytic domain

    14. XM_063261506.1 → XP_063117576.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X13

    15. XM_039111733.2 → XP_038967661.1  mitogen-activated protein kinase kinase kinase kinase 3 isoform X15

      UniProtKB/TrEMBL
      A0A0G2JYP2
      Conserved Domains (2) summary
      smart00036
      Location:406 → 749
      CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
      cl21453
      Location:1 → 96
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q924I2.2 GenPept UniProtKB/Swiss-Prot:Q924I2

    Gene LinkOut

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