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    mhc2a1 major histocompatibility complex class II integral membrane alpha chain gene 1 [ Danio rerio (zebrafish) ]

    Gene ID: 64691, updated on 8-Mar-2023

    Summary

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    Official Symbol
    mhc2a1provided by ZNC
    Official Full Name
    major histocompatibility complex class II integral membrane alpha chain gene 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040912-179
    See related
    AllianceGenome:ZFIN:ZDB-GENE-040912-179
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    a3; zgc:92049
    Summary
    Predicted to act upstream of or within adaptive immune response and antigen processing and presentation of peptide or polysaccharide antigen via MHC class II. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of MHC class II protein complex. [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    not in current annotation release
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    Bibliography

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    Related articles in PubMed

    1. Zebrafish Mhc class II alpha chain-encoding genes: polymorphism, expression, and function. Sültmann H, et al. Immunogenetics, 1993. PMID 8406613
    2. Molecular identification, polymorphism, and expression analysis of major histocompatibility complex class IIA and B genes of turbot (Scophthalmus maximus). Zhang YX, et al. Mar Biotechnol (NY), 2006 Nov-Dec. PMID 16832747
    3. Stimulatory function of peroxiredoxin 1 in activating adaptive humoral immunity in a zebrafish model. Liu GP, et al. Dev Comp Immunol, 2018 Jul. PMID 29518406
    4. Costimulatory Function of Cd58/Cd2 Interaction in Adaptive Humoral Immunity in a Zebrafish Model. Shao T, et al. Front Immunol, 2018. PMID 29904386, Free PMC Article
    5. Role of zebrafish NLRC5 in antiviral response and transcriptional regulation of MHC related genes. Wu XM, et al. Dev Comp Immunol, 2017 Mar. PMID 27876605

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Clone Names

    • MGC92049

    General protein information

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    Preferred Names
    major histocompatibility complex class II integral membrane alpha chain gene 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131695.1 → NP_571770.1  major histocompatibility complex class II integral membrane alpha chain gene 1 precursor

      See identical proteins and their annotated locations for NP_571770.1

      Status: PROVISIONAL

      Source sequence(s)
      L19450
      UniProtKB/TrEMBL
      Q31625
      Conserved Domains (3) summary
      smart00410
      Location:121 → 194
      IG_like; Immunoglobulin like
      pfam00993
      Location:22 → 99
      MHC_II_alpha; Class II histocompatibility antigen, alpha domain
      cl11960
      Location:103 → 197
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version

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