Rsph1 radial spoke head component 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rsph1provided by RGD
Official Full Name: radial spoke head component 1provided by RGD
Primary source: RGD:1307712
See related: Ensembl:ENSRNOG00000057862 AllianceGenome:RGD:1307712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tsga2
Summary: Predicted to be involved in axoneme assembly and spermatid development. Predicted to be located in condensed nuclear chromosome; cytoplasm; and cytoskeleton. Predicted to be active in cytosol; motile cilium; and nucleus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 24. Orthologous to human RSPH1 (radial spoke head component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 52.5), Testes (RPKM 46.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (9343258..9361988, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (9341910..9360640, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (9998698..10020719, complement)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

Rsph1 (e-PCR), detects polymorphism
- UniSTS:259668

AW433836 (e-PCR)
- UniSTS:248665

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in axoneme assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in spermatid development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spermatid development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	ISO Inferred from Sequence Orthology more info
located_in axoneme	ISO Inferred from Sequence Orthology more info
located_in condensed nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in meiotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in motile cilium	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in outer dense fiber	ISO Inferred from Sequence Orthology more info
part_of radial spoke	ISO Inferred from Sequence Orthology more info
part_of radial spoke head	ISO Inferred from Sequence Orthology more info
part_of radial spoke head 1	ISO Inferred from Sequence Orthology more info
part_of radial spoke head 3	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: radial spoke head 1 homolog

Names: testis specific gene A2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012176.1 → NP_001012176.1 radial spoke head 1 homolog

See identical proteins and their annotated locations for NP_001012176.1

Status: PROVISIONAL

Source sequence(s)

BC084704

UniProtKB/TrEMBL

A0A0G2K4W7, A0A0G2K6K4, A0A9K3Y812, F1LRG8, Q5XFW9

Related

ENSRNOP00000073201.2, ENSRNOT00000084726.2

Conserved Domains (3) summary

smart00698
Location:88 → 109

MORN; Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases

COG4642
Location:37 → 172

COG4642; Uncharacterized conserved protein [Function unknown]

pfam02493
Location:67 → 89

MORN; MORN repeat