Ckm creatine kinase, M-type [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ckmprovided by RGD
Official Full Name: creatine kinase, M-typeprovided by RGD
Primary source: RGD:2358
See related: Ensembl:ENSRNOG00000016837 AllianceGenome:RGD:2358
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ckmm; CPK-M
Summary: Enables creatine kinase activity. Involved in phosphocreatine biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in extracellular space. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 62235.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (88189382..88199717)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (79061390..79071721)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (80321507..80331841)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Creatine kinase inhibition also mimics a definitive characteristic of heart failure, the inability to respond to increased demand. Novel therapies for pulmonary artery hypertension are needed.
Title: Decreased creatine kinase is linked to diastolic dysfunction in rats with right heart failure induced by pulmonary artery hypertension.
strong down-regulation of MCK activity contributes to F-actin instability and induces post-translational modification of alphaB-crystallin and desmin
Title: Muscle creatine kinase deficiency triggers both actin depolymerization and desmin disorganization by advanced glycation end products in dilated cardiomyopathy.
effects of "right" and "left" E-box and "promoter" E-box mutations on Ckm expression in physiologically distinct muscles
Title: Differences in the function of three conserved E-boxes of the muscle creatine kinase gene in cultured myocytes and in transgenic mouse skeletal and cardiac muscle.
Data show that taurine minimizes lactic acidosis and preserves creatine kinase activity and myocardial contractility after ischemia/reperfusion.
Title: Regionally perfused taurine. Part I. Minimizes lactic acidosis and preserves CKMB and myocardial contractility after ischemia/reperfusion.
Characteristic fatigue resistance of extraocular muscles does not depend on creatine kinase(CK) activity. Expression of known CK isoforms is downregulated in these muscles.
Title: Fatigue resistance of rat extraocular muscles does not depend on creatine kinase activity.
Endotoxin-induced sepsis markedly reduced diaphragm and cardiac mitochondrial creatine kinase activity
Title: Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ckmm (e-PCR), detects polymorphism
- UniSTS:141346

Ckm (e-PCR), detects polymorphism
- UniSTS:472873

Ckmm (e-PCR), detects polymorphism
- UniSTS:238130

RH94390 (e-PCR)
- UniSTS:119638

X03233 (e-PCR)
- UniSTS:159603

RH138712 (e-PCR)
- UniSTS:220799

PMC125755P1 (e-PCR)
- UniSTS:270514

D1Bda2 (e-PCR)
- UniSTS:240336

AI324268 (e-PCR)
- UniSTS:208083

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables creatine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables creatine kinase activity	IEA Inferred from Electronic Annotation more info
enables creatine kinase activity	ISO Inferred from Sequence Orthology more info
enables creatine kinase activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in phosphocreatine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphocreatine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphocreatine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphocreatine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphocreatine biosynthetic process	TAS Traceable Author Statement more info	PubMed
involved_in response to heat	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: creatine kinase M-type

Names: M-CK; creatine kinase M chain; creatine kinase, muscle; creatine phosphokinase M-type

NP_036662.1

EC 2.7.3.2

XP_017444265.1

EC 2.7.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.