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    Srsf2 serine and arginine rich splicing factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 494445, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Srsf2provided by RGD
    Official Full Name
    serine and arginine rich splicing factor 2provided by RGD
    Primary source
    RGD:1359422
    See related
    Ensembl:ENSRNOG00000000248 AllianceGenome:RGD:1359422
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Sfrs2
    Summary
    Enables protein kinase C binding activity. Involved in mitotic cell cycle and response to vitamin E. Located in interchromatin granule; nuclear speck; and perichromatin fibrils. Human ortholog(s) of this gene implicated in acute myeloid leukemia; hepatocellular carcinoma; and myelodysplastic syndrome. Orthologous to human SRSF2 (serine and arginine rich splicing factor 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 877.7), Spleen (RPKM 660.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Srsf2 in Genome Data Viewer
    Location:
    10q32.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (102550962..102554200, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (102052158..102055365, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (105792779..105795986, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene jumonji domain containing 6, arginine demethylase and lysine hydroxylase Neighboring gene methyltransferase 23, arginine Neighboring gene major facilitator superfamily domain containing 11 Neighboring gene alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Exon 11 skipping of E-cadherin RNA downregulates its expression in head and neck cancer cells. Sharma S, et al. Mol Cancer Ther, 2011 Sep. PMID 21764905, Free PMC Article
    2. Recruitment of phosphorylated small heat shock protein Hsp27 to nuclear speckles without stress. Bryantsev AL, et al. Exp Cell Res, 2007 Jan 1. PMID 17123510, Free PMC Article
    3. Aging and vitamin E deficiency are responsible for altered RNA pathways. Malatesta M, et al. Ann N Y Acad Sci, 2004 Jun. PMID 15247049
    4. Mitotic partitioning and selective reorganization of tissue-specific transcription factors in progeny cells. Zaidi SK, et al. Proc Natl Acad Sci U S A, 2003 Dec 9. PMID 14657346, Free PMC Article
    5. Distribution of snRNPs, splicing factor SC-35 and actin in interphase nuclei: immunocytochemical evidence for differential distribution during changes in functional states. Sahlas DJ, et al. J Cell Sci, 1993 Jun. PMID 8408269

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. phosphorylated PKCdelta activates SC35 splicing factor during H9c2 cardiomyoblastic differentiation
      Title: pPKCδ activates SC35 splicing factor during H9c2 myoblastic differentiation.
    2. these results could indicate that myocardial tissue adaptation to low oxygen tension needs the activation of SC-35 mediated by PKC.
      Title: Effect of hypoxia and aging on PKC delta-mediated SC-35 phosphorylation in rat myocardial tissue.
    3. The role played by phospho-Protein Kinase C-alpha (p-PKCalpha) in regulating the activation of SC-35 splicing factor, was studied.
      Title: Protein kinase Calpha early activates splicing factor SC-35 during post-natal rat heart development.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73009

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pre-mRNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase C binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to vitamin E IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in interchromatin granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perichromatin fibrils IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    serine/arginine-rich splicing factor 2
    Names
    SC-35
    splicing component, 35 kDa
    splicing factor SC35
    splicing factor, arginine/serine-rich 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009720.2 → NP_001009720.1  serine/arginine-rich splicing factor 2

      See identical proteins and their annotated locations for NP_001009720.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q6PDU1
      UniProtKB/TrEMBL
      A6HL00
      Related
      ENSRNOP00000059012.1, ENSRNOT00000067739.3
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      102550962..102554200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008768382.3 → XP_008766604.1  serine/arginine-rich splicing factor 2 isoform X1

      See identical proteins and their annotated locations for XP_008766604.1

      UniProtKB/Swiss-Prot
      Q6PDU1
      UniProtKB/TrEMBL
      A6HL00
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    2. XM_006247813.5 → XP_006247875.1  serine/arginine-rich splicing factor 2 isoform X1

      See identical proteins and their annotated locations for XP_006247875.1

      UniProtKB/Swiss-Prot
      Q6PDU1
      UniProtKB/TrEMBL
      A6HL00
      Conserved Domains (1) summary
      cd12311
      Location:16 → 88
      RRM_SRSF2_SRSF8; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor SRSF2, SRSF8 and similar proteins

    RNA

    1. XR_005489902.2 RNA Sequence

    2. XR_358012.5 RNA Sequence

    3. XR_005489901.2 RNA Sequence

    4. XR_010055224.1 RNA Sequence

    5. XR_010055223.1 RNA Sequence

    6. XR_010055222.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDU1.3 GenPept UniProtKB/Swiss-Prot:Q6PDU1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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