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    Norad non-coding RNA activated by DNA damage [ Mus musculus (house mouse) ]

    Gene ID: 347740, updated on 9-May-2024

    Summary

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    Official Symbol
    Noradprovided by MGI
    Official Full Name
    non-coding RNA activated by DNA damageprovided by MGI
    Primary source
    MGI:MGI:1914767
    See related
    Ensembl:ENSMUSG00000102869 AllianceGenome:MGI:1914767
    Gene type
    ncRNA
    RefSeq status
    PREDICTED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810005K14Rik; 2900097C17Rik; 4930563C06Rik
    Summary
    Is expressed in embryo. Orthologous to human NORAD (non-coding RNA activated by DNA damage). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See Norad in Genome Data Viewer
    Location:
    2 H1; 2 77.39 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (156229983..156234899, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (156388063..156392979, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene cyclic nucleotide binding domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_06163 Neighboring gene STARR-positive B cell enhancer mm9_chr2:156182424-156182725 Neighboring gene programmed cell death 10 pseudogene Neighboring gene predicted gene 14170 Neighboring gene ribosomal protein L21, pseudogene 9 Neighboring gene ribosomal protein L37a pseudogene Neighboring gene erythrocyte membrane protein band 4.1 like 1 Neighboring gene STARR-seq mESC enhancer starr_06170 Neighboring gene STARR-seq mESC enhancer starr_06171 Neighboring gene predicted gene, 33977

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PUMILIO hyperactivity drives premature aging of Norad-deficient mice. Kopp F, et al. Elife, 2019 Feb 8. PMID 30735131, Free PMC Article
    2. LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis. Li C, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Apr 25. PMID 35607965, Free PMC Article
    3. WTAP-mediated m(6)A modification of lncRNA NORAD promotes intervertebral disc degeneration. Li G, et al. Nat Commun, 2022 Mar 18. PMID 35304463, Free PMC Article
    4. Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5. Fu DN, et al. Exp Cell Res, 2021 Apr 15. PMID 33636159
    5. The treasury of the commons: making use of public gene expression resources to better characterize the molecular diversity of inhibitory interneurons in the cerebellar cortex. Schilling K, et al. Cerebellum, 2009 Dec. PMID 19554387

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis.
      Title: LncRNA NORAD promotes the progression of myocardial infarction by targeting the miR-22-3p/PTEN axis.
    2. Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Kruppel-like factor 5.
      Title: Silenced long non-coding RNA activated by DNA damage elevates microRNA-495-3p to suppress atherosclerotic plaque formation via reducing Krüppel-like factor 5.
    3. Norad is the preferred RNA target of PUMILIO2 (PUM2) in mouse tissues and, upon loss of Norad, PUM2 hyperactively represses key genes required for mitosis and mitochondrial function. Accordingly, enforced Pum2 expression fully phenocopies Norad deletion, resulting in rapid-onset aging-associated phenotypes.
      Title: PUMILIO hyperactivity drives premature aging of Norad-deficient mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (1) 

    General gene information

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    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chromosome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hair follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in reactive oxygen species metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in skeletal system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tissue homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024329.1 RNA Sequence

      Status: PREDICTED

      Source sequence(s)
      AK077867, AL928935, BM898641
      Related
      ENSMUST00000192863.4

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      156229983..156234899 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases