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    XRCC4 DNA ligase IV-binding protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821885, updated on 7-Sep-2023

    Summary

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    Gene symbol
    XRCC4
    Gene description
    DNA ligase IV-binding protein
    Primary source
    Araport:AT3G23100
    Locus tag
    AT3G23100
    See related
    TAIR:AT3G23100
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    homolog of human DNA ligase iv-binding protein XRCC4; homolog of X-ray repair cross complementing 4
    Summary
    A. thaliana homologue of the human DNA ligase IV-binding protein XRCC4. Yeast two-hybrid analysis demonstrated a strong interaction between A. thaliana DNA ligase IV and the A. thaliana homologue of the human DNA ligase IV-binding protein XRCC4. This interaction is shown to be mediated via the tandem BRCA C-terminal domains of A. thaliana DNA ligase IV protein.
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    Genomic context

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    See XRCC4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    6
    Sequence:
    Chromosome: 3; NC_003074.8 (8220682..8226400)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene TPX2 (targeting protein for Xklp2) protein family Neighboring gene receptor like protein 37 Neighboring gene miscRNA Neighboring gene receptor like protein 38

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Agrobacterium may delay plant nonhomologous end-joining DNA repair via XRCC4 to favor T-DNA integration. Vaghchhipawala ZE, et al. Plant Cell, 2012 Oct. PMID 23064322, Free PMC Article
    2. Involvement of AtPolλ in the repair of high salt- and DNA cross-linking agent-induced double strand breaks in Arabidopsis. Roy S, et al. Plant Physiol, 2013 Jun. PMID 23660835, Free PMC Article
    3. Arabidopsis DNA ligase IV is induced by gamma-irradiation and interacts with an Arabidopsis homologue of the double strand break repair protein XRCC4. West CE, et al. Plant J, 2000 Oct. PMID 11029705
    4. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. XRCC4 has a negative role in Agrobacterium T-DNA integration.
      Title: Agrobacterium may delay plant nonhomologous end-joining DNA repair via XRCC4 to favor T-DNA integration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001161167.1
    NM_113211.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA ligase IV-binding protein
    NP_001154639.1
    • homolog of human DNA ligase iv-binding protein XRCC4 (XRCC4); FUNCTIONS IN: protein C-terminus binding; INVOLVED IN: double-strand break repair, DNA recombination, metabolic process; LOCATED IN: nucleus; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), DNA double-strand break repair and VJ recombination XRCC4, C-terminal (InterPro:IPR014751), DNA double-strand break repair and VJ recombination XRCC4 (InterPro:IPR010585); BEST Arabidopsis thaliana protein match is: DNA double-strand break repair and VJ recombination XRCC4 (TAIR:AT1G61410.1); Has 189 Blast hits to 182 proteins in 54 species: Archae - 0; Bacteria - 3; Metazoa - 88; Fungi - 4; Plants - 48; Viruses - 0; Other Eukaryotes - 46 (source: NCBI BLink).
    NP_188951.2
    • homolog of human DNA ligase iv-binding protein XRCC4 (XRCC4); FUNCTIONS IN: protein C-terminus binding; INVOLVED IN: double-strand break repair, metabolic process, DNA recombination; LOCATED IN: nucleus; EXPRESSED IN: 15 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Carbamoyl phosphate synthetase, large subunit, ATP-binding (InterPro:IPR005479), DNA double-strand break repair and VJ recombination XRCC4, C-terminal (InterPro:IPR014751), DNA double-strand break repair and VJ recombination XRCC4 (InterPro:IPR010585); BEST Arabidopsis thaliana protein match is: DNA double-strand break repair and VJ recombination XRCC4 (TAIR:AT1G61410.1); Has 189 Blast hits to 182 proteins in 54 species: Archae - 0; Bacteria - 3; Metazoa - 88; Fungi - 4; Plants - 48; Viruses - 0; Other Eukaryotes - 46 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8220682..8226400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001161167.1 → NP_001154639.1  DNA ligase IV-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001154639.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682V0, Q9LS81
      UniProtKB/TrEMBL
      A0A654F9V8
      Conserved Domains (1) summary
      pfam06632
      Location:47 → 256
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4

    2. NM_113211.2 → NP_188951.2  DNA ligase IV-binding protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188951.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q682V0, Q9LS81
      UniProtKB/TrEMBL
      A0A654F9V8
      Conserved Domains (1) summary
      pfam06632
      Location:47 → 256
      XRCC4; DNA double-strand break repair and V(D)J recombination protein XRCC4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q682V0.2

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