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    ETR2 Signal transduction histidine kinase, hybrid-type, ethylene sensor [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821891, updated on 15-Oct-2023

    Summary

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    Gene symbol
    ETR2
    Gene description
    Signal transduction histidine kinase, hybrid-type, ethylene sensor
    Primary source
    Araport:AT3G23150
    Locus tag
    AT3G23150
    See related
    TAIR:AT3G23150
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ethylene response 2
    Summary
    Involved in ethylene perception in Arabidopsis
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    Genomic context

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    See ETR2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    3
    Sequence:
    Chromosome: 3; NC_003074.8 (8254559..8257888)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene C2H2 and C2HC zinc fingers superfamily protein Neighboring gene ATP binding / aminoacyl-tRNA ligase/ nucleotide binding protein Neighboring gene plant/protein (DUF668) Neighboring gene low-molecular-weight cysteine-rich 42

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ethylene receptor ETR2 controls trichome branching by regulating microtubule assembly in Arabidopsis thaliana. Plett JM, et al. J Exp Bot, 2009. PMID 19648171, Free PMC Article
    2. Ligand-induced degradation of the ethylene receptor ETR2 through a proteasome-dependent pathway in Arabidopsis. Chen YF, et al. J Biol Chem, 2007 Aug 24. PMID 17595158
    3. ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis. Sakai H, et al. Proc Natl Acad Sci U S A, 1998 May 12. PMID 9576967, Free PMC Article
    4. Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses. Bakshi A, et al. Plant Physiol, 2018 Jan. PMID 29158332, Free PMC Article
    5. Ethylene Regulates Levels of Ethylene Receptor/CTR1 Signaling Complexes in Arabidopsis thaliana. Shakeel SN, et al. J Biol Chem, 2015 May 8. PMID 25814663, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ETR1 and ETR2 have both ethylene-dependent and -independent roles in plant cells that affect responses to abscissic acid.
      Title: Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses.
    2. ETR1, ETR2, and ETHYLENE INSENSITIVE4 (EIN4) have the prominent roles in rapid growth recovery after removal of ethylene whereas ETR1 was the sole isoform that rescued nutations.
      Title: Ethylene receptor ETHYLENE RECEPTOR1 domain requirements for ethylene responses in Arabidopsis seedlings.
    3. ETR2 controls trichome branching by regulating microtubule assembly.
      Title: Ethylene receptor ETR2 controls trichome branching by regulating microtubule assembly in Arabidopsis thaliana.
    4. ETR2 is degraded by a proteasome-dependent pathway in response to ethylene binding
      Title: Ligand-induced degradation of the ethylene receptor ETR2 through a proteasome-dependent pathway in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001338618.1
    NM_113216.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ethylene binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethylene receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein histidine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to hypoxia HEP PubMed 
    acts_upstream_of_or_within negative regulation of ethylene-activated signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    Signal transduction histidine kinase, hybrid-type, ethylene sensor
    NP_188956.1
    • ethylene response 2 (ETR2); FUNCTIONS IN: ethylene binding, protein histidine kinase activity, receptor activity, glycogen synthase kinase 3 activity; INVOLVED IN: negative regulation of ethylene mediated signaling pathway; LOCATED IN: endomembrane system, endoplasmic reticulum membrane, membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 7 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CheY-like (InterPro:IPR011006), Signal transduction histidine kinase, hybrid-type, ethylene sensor (InterPro:IPR014525), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), GAF (InterPro:IPR003018); BEST Arabidopsis thaliana protein match is: Signal transduction histidine kinase, hybrid-type, ethylene sensor (TAIR:AT3G04580.2); Has 29902 Blast hits to 25922 proteins in 2098 species: Archae - 92; Bacteria - 25510; Metazoa - 11; Fungi - 1191; Plants - 1553; Viruses - 6; Other Eukaryotes - 1539 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      8254559..8257888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113216.3 → NP_188956.1  Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82429, Q0WPQ2, Q9LTD5
      UniProtKB/TrEMBL
      A0A5S9XF35, A0A654F9W5
      Conserved Domains (4) summary
      cd16938
      Location:470 → 612
      HATPase_ETR2_ERS2-EIN4-like; Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains
      cd19933
      Location:646 → 762
      REC_ETR-like; phosphoacceptor receiver (REC) domain of plant ethylene receptors ETR1, ETR2, and EIN4, and similar proteins
      pfam00512
      Location:367 → 425
      HisKA; His Kinase A (phospho-acceptor) domain
      pfam01590
      Location:187 → 331
      GAF; GAF domain

    2. NM_001338618.1 → NP_001326955.1  Signal transduction histidine kinase, hybrid-type, ethylene sensor [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1I9LQU7
      Conserved Domains (3) summary
      PRK11466
      Location:344 → 494
      PRK11466; hybrid sensory histidine kinase TorS; Provisional
      cd16938
      Location:470 → 589
      HATPase_ETR2_ERS2-EIN4-like; Histidine kinase-like ATPase domain of Arabidopsis thaliana ETR2, ERS2, and EIN4, and related domains
      pfam01590
      Location:187 → 331
      GAF; GAF domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0WPQ2.2

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