Tpo thyroid peroxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tpoprovided by RGD
Official Full Name: thyroid peroxidaseprovided by RGD
Primary source: RGD:3900
See related: Ensembl:ENSRNOG00000004646 AllianceGenome:RGD:3900
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable iodide peroxidase activity. Involved in cellular response to nitric oxide and response to lipid. Located in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in congenital hypothyroidism; glomerulonephritis; and thyroid dyshormonogenesis 2A. Orthologous to human TPO (thyroid peroxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (52425998..52495793, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (46698402..46768199, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (49020918..49089855, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors.
Title: Allylpyrocatechol, isolated from betel leaf ameliorates thyrotoxicosis in rats by altering thyroid peroxidase and thyrotropin receptors.
Nitric oxide decreases TSH-induced FoxE1 expression, thus repressing the transcripcional activation of TPO gene.
Title: Nitric oxide-repressed Forkhead factor FoxE1 expression is involved in the inhibition of TSH-induced thyroid peroxidase levels.
SREBP-1c and SREBP-2 are regulators of the rat thyroid peroxidase gene in thyroid cells
Title: Sterol regulatory element-binding proteins are regulators of the rat thyroid peroxidase gene in thyroid cells.
Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-kappaB p65 subunit phosphorylation
Title: Thyroid peroxidase gene expression is induced by lipopolysaccharide involving nuclear factor (NF)-κB p65 subunit phosphorylation.
Aammonium perchlorate can decrease the mRNA expression levels of Tg and TPO in the thyroid.
Title: [The effects of ammonium perchlorate on thyroid function and mRNA expression of thyroglobulin and thyroperoxidase].
Compared with the control group, the TPO mRNA levels of the propylthiouracil-treated group were increased, while the Tg mRNA levels were decreased significantly.
Title: [Effect of PTU on the expression of thyroid TPO, Tg mRNA in rats].
A novel property of nitric oxide to inhibit TPO and thyroglobulin mRNA expression is supported
Title: Nitric oxide/cGMP signaling inhibits TSH-stimulated iodide uptake and expression of thyroid peroxidase and thyroglobulin mRNA in FRTL-5 thyroid cells.
Results suggest that FoxE1 is a pioneer factor whose primary mechanistic role in mediating the hormonal regulation of the thyroperoxidase gene is to enable other regulatory factors to access the chromatin.
Title: The forkhead factor FoxE1 binds to the thyroperoxidase promoter during thyroid cell differentiation and modifies compacted chromatin structure.
Endocrine disruptor chemicals, most potently Benzophenone-2, may disturb TH homeostasis by inhibiting or inactivating TPO, effects that are even more pronounced in the absence of iodide.
Title: The ultraviolet filter benzophenone 2 interferes with the thyroid hormone axis in rats and is a potent in vitro inhibitor of human recombinant thyroid peroxidase.
in FRTL5 cells, a large fraction of rTPO is delivered to the plasma membrane yet does not acquire Golgi-type processing of its N-glycans
Title: Intracellular trafficking of thyroid peroxidase to the cell surface.

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General gene information

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Markers

RH94606 (e-PCR)
- UniSTS:119854

Tpo (e-PCR), detects polymorphism
- UniSTS:516181

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iodide peroxidase activity	IEA Inferred from Electronic Annotation more info
enables iodide peroxidase activity	ISO Inferred from Sequence Orthology more info
enables iodide peroxidase activity	TAS Traceable Author Statement more info	PubMed
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in cellular response to nitric oxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic hemopoiesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in hormone biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide catabolic process	IEA Inferred from Electronic Annotation more info
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	IEA Inferred from Electronic Annotation more info
involved_in thyroid hormone generation	ISO Inferred from Sequence Orthology more info
involved_in thyroid hormone generation	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thyroid peroxidase

NP_062226.2

EC 1.11.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019353.2 → NP_062226.2 thyroid peroxidase precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6HB29, F1LN48

Related

ENSRNOP00000006526.1, ENSRNOT00000006526.4

Conserved Domains (4) summary

cd00033
Location:730 → 783

CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system

cd09825
Location:161 → 722

thyroid_peroxidase; Thyroid peroxidase (TPO)

pfam07645
Location:784 → 813

EGF_CA; Calcium-binding EGF domain

pfam14670
Location:802 → 826

FXa_inhibition; Coagulation Factor Xa inhibitory site