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    Cuta cutA divalent cation tolerance homolog [ Rattus norvegicus (Norway rat) ]

    Gene ID: 294288, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Cutaprovided by RGD
    Official Full Name
    cutA divalent cation tolerance homologprovided by RGD
    Primary source
    RGD:1303306
    See related
    Ensembl:ENSRNOG00000000481 AllianceGenome:RGD:1303306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CutA1
    Summary
    Predicted to enable copper ion binding activity and enzyme binding activity. Involved in protein localization. Predicted to be located in membrane. Orthologous to human CUTA (cutA divalent cation tolerance homolog). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 94.3), Heart (RPKM 93.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Cuta in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (5024816..5026446, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (5022956..5024580, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (5532024..5533640, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene kinesin family member C1 Neighboring gene PHD finger protein 1 Neighboring gene synaptic Ras GTPase activating protein 1 Neighboring gene zinc finger and BTB domain containing 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase. Liang D, et al. J Biol Chem, 2009 Feb 20. PMID 19049969
    2. Two distinct proteins are associated with tetrameric acetylcholinesterase on the cell surface. Perrier AL, et al. J Biol Chem, 2000 Nov 3. PMID 10954708
    3. Hydrophobic protein that copurifies with human brain acetylcholinesterase: amino acid sequence, genomic organization, and chromosomal localization. Navaratnam DS, et al. J Neurochem, 2000 May. PMID 10800960
    4. The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction. Arnesano F, et al. J Biol Chem, 2003 Nov 14. PMID 12949080
    5. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, et al. Genome Res, 2004 Apr. PMID 15060004, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase.
      Title: Protein CutA undergoes an unusual transfer into the secretory pathway and affects the folding, oligomerization, and secretion of acetylcholinesterase.
    2. comparative x-ray crystallography analysis suggests CutA1 proteins have a role in signal transduction through allosteric communications between subunits.
      Title: The evolutionarily conserved trimeric structure of CutA1 proteins suggests a role in signal transduction.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables enzyme binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to metal ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein CutA
    Names
    brain acetylcholinesterase putative membrane anchor
    divalent cation tolerant protein CUTA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164706.1 → NP_001158178.1  protein CutA isoform 2 precursor

      See identical proteins and their annotated locations for NP_001158178.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
      Source sequence(s)
      BX883042, CB586341
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A0A0G2JT00, A6JJJ6
      Related
      ENSRNOP00000065219.1, ENSRNOT00000072319.4
      Conserved Domains (1) summary
      pfam03091
      Location:46 → 141
      CutA1; CutA1 divalent ion tolerance protein

    2. NM_001164707.1 → NP_001158179.1  protein CutA isoform 2 precursor

      See identical proteins and their annotated locations for NP_001158179.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream start codon compared to variant 1. Both variants 2 and 3 encode the same protein (isoform 2), which is shorter than isoform 1.
      Source sequence(s)
      BP501235, BX883042, DV717217
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A0A0G2JT00, A6JJJ6
      Conserved Domains (1) summary
      pfam03091
      Location:46 → 141
      CutA1; CutA1 divalent ion tolerance protein

    3. NM_212494.2 → NP_997659.2  protein CutA isoform 1 precursor

      See identical proteins and their annotated locations for NP_997659.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BX883042
      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A6JJJ5, G3V616
      Related
      ENSRNOP00000000568.2, ENSRNOT00000000568.7
      Conserved Domains (1) summary
      pfam03091
      Location:69 → 164
      CutA1; CutA1 divalent ion tolerance protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      5024816..5026446 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006256120.5 → XP_006256182.1  protein CutA isoform X1

      See identical proteins and their annotated locations for XP_006256182.1

      UniProtKB/Swiss-Prot
      Q6MGD0
      UniProtKB/TrEMBL
      A6JJJ5, G3V616
      Conserved Domains (1) summary
      pfam03091
      Location:69 → 164
      CutA1; CutA1 divalent ion tolerance protein

    RNA

    1. XR_005497189.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6MGD0.2 GenPept UniProtKB/Swiss-Prot:Q6MGD0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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