Zfp622 zinc finger protein 622 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Zfp622provided by RGD
Full Name: zinc finger protein 622provided by RGD
Primary source: RGD:1309146
See related: Ensembl:ENSRNOG00000010589 AllianceGenome:RGD:1309146
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf622
Summary: Predicted to enable nucleic acid binding activity and zinc ion binding activity. Predicted to be involved in several processes, including intrinsic apoptotic signaling pathway in response to oxidative stress; positive regulation of JNK cascade; and positive regulation of kinase activity. Predicted to be located in Golgi apparatus; cytosol; and nuclear lumen. Predicted to be part of preribosome, large subunit precursor. Orthologous to human ZNF622 (zinc finger protein 622). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 74.7), Kidney (RPKM 71.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q22

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (78205655..78224888)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (76479605..76494405)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (78407312..78421152)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU016070 (e-PCR)
- UniSTS:180741

REN91033 (e-PCR)
- UniSTS:415831

RH134526 (e-PCR)
- UniSTS:217806

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables preribosome binding	ISO Inferred from Sequence Orthology more info
enables preribosome binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ribosomal large subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal large subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosome biogenesis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of preribosome, large subunit precursor	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytoplasmic 60S subunit biogenesis factor ZNF622

Names: liver regeneration-related protein LRRG121

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009652.1 → NP_001009652.1 cytoplasmic 60S subunit biogenesis factor ZNF622

See identical proteins and their annotated locations for NP_001009652.1

Status: PROVISIONAL

Source sequence(s)

BC088214

UniProtKB/TrEMBL

A0A8L2URM4, F1LQ57, Q5M855

Related

ENSRNOP00000075424.2, ENSRNOT00000084541.2

Conserved Domains (3) summary

sd00020
Location:6 → 28

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam12171
Location:68 → 91

zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

pfam12756
Location:247 → 346

zf-C2H2_2; C2H2 type zinc-finger (2 copies)